Bicifadine hydrochloride
Biological Activity
Potent antagonist of the noradrenalin transporter (IC50 = 55 nM); also displays antagonist activity at the 5-HT and dopamine transporters (IC50 values are 117 nM and 910 nM respectively). Orally active. Exhibits antinociceptive and antiallodynic activity in rodent models of acute, persistent, and chronic pain.
Compound Libraries
Bicifadine hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 209.72 |
| Formula | C12H15N.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 66504-75-4 |
| PubChem ID | 47952 |
| InChI Key | OTZOPAFTLUOBOM-UHFFFAOYSA-N |
| Smiles | CC(C=C3)=CC=C3C12CNCC1C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20.97 | 100 | |
| DMSO | 20.97 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 209.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.77 mL | 23.84 mL | 47.68 mL |
| 5 mM | 0.95 mL | 4.77 mL | 9.54 mL |
| 10 mM | 0.48 mL | 2.38 mL | 4.77 mL |
| 50 mM | 0.1 mL | 0.48 mL | 0.95 mL |
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References
References are publications that support the biological activity of the product.
Epstein (1981) 1-Aryl-3-azabicyclo[3.1.0]hexanes, a new series of nonnarcotic analgesic agents. J.Med.Chem. 24 481 PMID: 7241504
Basile (2007) Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. J.Pharmacol.Exp.Ther 321 1208 PMID: 17325229
If you know of a relevant reference for Bicifadine hydrochloride, please let us know.
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Citations for Bicifadine hydrochloride
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