Bicifadine hydrochloride

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Cat.No. 4357 - Bicifadine hydrochloride | C12H15N.HCl | CAS No. 66504-75-4
Description: Noradrenalin, 5-HT and dopamine re-uptake inhibitor
Chemical Name: 1-(4-Methylphenyl)-3-azabicyclo[3.1.0]hexane hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Potent antagonist of the noradrenalin transporter (IC50 = 55 nM); also displays antagonist activity at the 5-HT and dopamine transporters (IC50 values are 117 nM and 910 nM respectively). Orally active. Exhibits antinociceptive and antiallodynic activity in rodent models of acute, persistent, and chronic pain.

Compound Libraries

Bicifadine hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 209.72
Formula C12H15N.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 66504-75-4
PubChem ID 47952
Smiles CC(C=C3)=CC=C3C12CNCC1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.97 100
water 20.97 100

Preparing Stock Solutions

The following data is based on the product molecular weight 209.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.77 mL 23.84 mL 47.68 mL
5 mM 0.95 mL 4.77 mL 9.54 mL
10 mM 0.48 mL 2.38 mL 4.77 mL
50 mM 0.1 mL 0.48 mL 0.95 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Epstein (1981) 1-Aryl-3-azabicyclo[3.1.0]hexanes, a new series of nonnarcotic analgesic agents. J.Med.Chem. 24 481 PMID: 7241504

Basile (2007) Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. J.Pharmacol.Exp.Ther 321 1208 PMID: 17325229

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