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Submit ReviewBicifadine hydrochloride
Description: Noradrenalin, 5-HT and dopamine re-uptake inhibitor
Chemical Name: 1-(4-Methylphenyl)-3-azabicyclo[3.1.0]hexane hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Bicifadine hydrochloride
Bicifadine hydrochloride is a potent antagonist of the noradrenalin transporter (IC50 = 55 nM); also displays antagonist activity at the 5-HT and dopamine transporters (IC50 values are 117 nM and 910 nM respectively). Orally active. Exhibits antinociceptive and antiallodynic activity in rodent models of acute, persistent, and chronic pain.
Technical Data for Bicifadine hydrochloride
| M. Wt | 209.72 |
| Formula | C12H15N.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 66504-75-4 |
| PubChem ID | 47952 |
| InChI Key | OTZOPAFTLUOBOM-UHFFFAOYSA-N |
| Smiles | CC(C=C3)=CC=C3C12CNCC1C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Bicifadine hydrochloride
References for Bicifadine hydrochloride
References are publications that support the biological activity of the product.
Epstein (1981) 1-Aryl-3-azabicyclo[3.1.0]hexanes, a new series of nonnarcotic analgesic agents. J.Med.Chem. 24 481 PMID: 7241504
Basile (2007) Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. J.Pharmacol.Exp.Ther 321 1208 PMID: 17325229
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