You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
BIBU 1361 dihydrochloride
Biological Activity for BIBU 1361 dihydrochloride
BIBU 1361 dihydrochloride is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC50 > 10 μM). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice.
Technical Data for BIBU 1361 dihydrochloride
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BIBU 1361 dihydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BIBU 1361 dihydrochloride
The following data is based on the product molecular weight 516.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.93 mL||9.67 mL||19.35 mL|
|5 mM||0.39 mL||1.93 mL||3.87 mL|
|10 mM||0.19 mL||0.97 mL||1.93 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
Product Datasheets for BIBU 1361 dihydrochloride
References for BIBU 1361 dihydrochloride
References are publications that support the biological activity of the product.
Solca et al (2004) Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J.Pharmacol.Exp.Ther. 311 502 PMID: 15199094
If you know of a relevant reference for BIBU 1361 dihydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: BIBU 1361 dihydrochloride, BIBU 1361 dihydrochloride supplier, Selective, inhibitors, inhibits, EGFR-kinases, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, BIBU1361, dihydrochloride, EGFR, 2417, Tocris Bioscience
Citations for BIBU 1361 dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for BIBU 1361 dihydrochloride. Do you know of a great paper that uses BIBU 1361 dihydrochloride from Tocris? Please let us know.
Reviews for BIBU 1361 dihydrochloride
There are currently no reviews for this product. Be the first to review BIBU 1361 dihydrochloride and earn rewards!
Have you used BIBU 1361 dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.