Potent and selective BRD9 and BRD7 inhibitor (Kd values are 14 and 239 nM, respectively). Exhibits selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo. Cell permeable and orally active.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 9564 probe summary on the SGC website.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BI-9564 is reviewed on the chemical probes website.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|1eq. HCl||3.53||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 353.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.83 mL||14.15 mL||28.3 mL|
|5 mM||0.57 mL||2.83 mL||5.66 mL|
|10 mM||0.28 mL||1.41 mL||2.83 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Martin et al (2016) Structure-based design of an in vivo active selective BRD9 inhibitor J.Med.Chem. 59 4462 PMID: 26914985
Karim and Schönbrunn (2016) An Advanced Tool To Interrogate BRD9. J.Med.Chem. 59 4459 PMID: 27120693
If you know of a relevant reference for BI 9564, please let us know.
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Keywords: BI9564 BRD9 BRD7 potent selective inhibitors inhibits bromodomains orally active Bromodomains
Citations for BI 9564
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