BI 9321

Pricing Availability   Qty
Description: Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain
Chemical Name: (4-(5-(7-Fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylphenyl)methanamine trihydrochloride
Purity: ≥98% (HPLC)

Biological Activity for BI 9321

BI 9321 is a nuclear receptor-binding SET domain (NSD) 3 antagonist (IC50 = 1.2 μM). Selectively binds the PWWP1 domain of NSD3 (Kd = 166 nM). Antagonizes the interaction of H3 with NSD3-PWWP1 in U2OS cells.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 9321 probe summary on the SGC website.

Technical Data for BI 9321

M. Wt 469.81
Formula C22H21FN4.3HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 2387510-87-2
Smiles CN1C=NC(C2=C(C=C(C=C2C)CN)C)=C1C3=C4C=CC(F)=CC4=NC=C3.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BI 9321

Solvent Max Conc. mg/mL Max Conc. mM
water 46.98 100
DMSO 46.98 100

Preparing Stock Solutions for BI 9321

The following data is based on the product molecular weight 469.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.64 mL 21.29 mL
5 mM 0.43 mL 2.13 mL 4.26 mL
10 mM 0.21 mL 1.06 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for BI 9321

References are publications that support the biological activity of the product.

Böttcher et al (2019) Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat.Chem.Biol. 15 822 PMID: 31285596

If you know of a relevant reference for BI 9321, please let us know.

View Related Products by Product Action

View all Other Lysine Methyltransferase Inhibitors

Keywords: BI 9321, BI 9321 supplier, BI9321, nuclear, receptor-binding, SET, domain, 3, NSD3, antagonists, antagonism, lysine, methyltransferases, Other, Lysine, Methyltransferases, 6665, Tocris Bioscience

Citations for BI 9321

Citations are publications that use Tocris products.

Currently there are no citations for BI 9321. Do you know of a great paper that uses BI 9321 from Tocris? Please let us know.

Reviews for BI 9321

There are currently no reviews for this product. Be the first to review BI 9321 and earn rewards!

Have you used BI 9321?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review