BI 9321

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Cat.No. 6665 - BI 9321 | C22H21FN4.3HCl
Description: Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain
Chemical Name: (4-(5-(7-Fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylphenyl)methanamine trihydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Nuclear receptor-binding SET domain (NSD) 3 antagonist (IC50 = 1.2 μM). Selectively binds the PWWP1 domain of NSD3 (Kd = 166 nM). Antagonizes the interaction of H3 with NSD3-PWWP1 in U2OS cells.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 9321 probe summary on the SGC website.

Technical Data

M. Wt 469.81
Formula C22H21FN4.3HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
Smiles CN1C=NC(C2=C(C=C(C=C2C)CN)C)=C1C3=C4C=CC(F)=CC4=NC=C3.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 46.98 100
DMSO 46.98 100

Preparing Stock Solutions

The following data is based on the product molecular weight 469.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.64 mL 21.29 mL
5 mM 0.43 mL 2.13 mL 4.26 mL
10 mM 0.21 mL 1.06 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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References are publications that support the biological activity of the product.

Böttcher et al (2019) Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat.Chem.Biol. 15 822 PMID: 31285596

If you know of a relevant reference for BI 9321, please let us know.

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Keywords: BI 9321, BI 9321 supplier, BI9321, nuclear, receptor-binding, SET, domain, 3, NSD3, antagonists, antagonism, lysine, methyltransferases, Other, Lysine, Methyltransferases, 6665, Tocris Bioscience

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