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Cat.No. 1236 - BHQ | C14H22O2 | CAS No. 88-58-4
Description: Inhibitor of SERCA ATPase
Chemical Name: 1,4-Dihydroxy-2,5-di-tert-butylbenzene
Citations (3)

Biological Activity

A selective inhibitor of endoplasmic reticulum Ca2+-ATPase.

Technical Data

M. Wt 222.33
Formula C14H22O2
Storage Store at RT
CAS Number 88-58-4
PubChem ID 2374
Smiles CC(C)(C)C1=CC(O)=C(C=C1O)C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 222.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.5 mL 22.49 mL 44.98 mL
5 mM 0.9 mL 4.5 mL 9 mL
10 mM 0.45 mL 2.25 mL 4.5 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

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References are publications that support the products' biological activity.

Dettbarn and Palade (1999) Effects of three sarcoplasmic/endoplasmic Ca++ pump inhibitors on release channels and intracellular stores. J.Pharmacol.Exp.Ther. 285 739 PMID: 9580621

Fusi et al (1999) 2,5-Di-t-butyl-1,4 benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta. Eur.J.Pharmacol. 366 181 PMID: 10082199

Hassessian et al (1994) Blockade of the inward rectifier potassium current by the Ca2+-ATPase inhibitor 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ). Br.J.Pharmacol. 112 1118 PMID: 7952872

Jan et al (1999) Mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced Ca2+ signals in Madin Darby canine kidney cells. Eur.J.Pharmacol. 365 111 PMID: 9988129

If you know of a relevant reference for BHQ, please let us know.

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Keywords: inhibitors inhibits SERCA ATPase Ca2+ modulators Ca2+-ATPase Signaling Signalling Calcium P-Type ATPases Calcium-ATPase Ion Transporters Pumps Ca2+-ATPase

3 Citations for BHQ

Citations are publications that use Tocris products. Selected citations for BHQ include:

Zhdanov et al (2011) Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria. Cell Mol Life Sci 68 903 PMID: 20820851

Inagaki et al (2014) Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca2+ channel due to a familial hemiplegic migraine mutation. Neuron 81 91 PMID: 24411734

Dai et al (2012) Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells. J Biol Chem 287 14586 PMID: 22418436

Do you know of a great paper that uses BHQ from Tocris? If so please let us know.

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