BF 2649 hydrochloride

Pricing Availability   Qty
Description: Potent and selective H3 inverse agonist
Chemical Name: 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidine hydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for BF 2649 hydrochloride

BF 2649 hydrochloride is a potent and selective histamine H3 receptor inverse agonist (EC50 = 1.5 nM, Ki = 0.16 nM). Exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Brain penetrant.

Compound Libraries for BF 2649 hydrochloride

BF 2649 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BF 2649 hydrochloride

M. Wt 332.31
Formula C17H26ClNO.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 903576-44-3
PubChem ID 11551689

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BF 2649 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 33.23 100
DMSO 33.23 100

Preparing Stock Solutions for BF 2649 hydrochloride

The following data is based on the product molecular weight 332.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.05 mL 30.09 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for BF 2649 hydrochloride

Certificate of Analysis / Product Datasheet
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References for BF 2649 hydrochloride

References are publications that support the biological activity of the product.

Ligneau et al (2007) Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. Biochem.Pharmacol. 73 1215 PMID: 17343831

Ligneau et al (2007) BF2.649 [1-{3-{3-(4-chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J.Pharm.Exp.Ther. 320 365 PMID: 17005916

If you know of a relevant reference for BF 2649 hydrochloride, please let us know.

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Citations for BF 2649 hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.