BF 2649 hydrochloride

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Cat.No. 3743 - BF 2649 hydrochloride | C17H26ClNO.HCl | CAS No. 903576-44-3
Description: H3 receptor inverse agonist/antagonist
Chemical Name: 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Histamine H3 receptor inverse agonist (EC50 = 1.5 nM) and antagonist (Ki = 0.16 nM). Exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Brain penetrant.

Compound Libraries

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Technical Data

M. Wt 332.31
Formula C17H26ClNO.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 903576-44-3
PubChem ID 11551689
InChI Key XLFKECRRMPOAQS-UHFFFAOYSA-N
Smiles ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.23 100
ethanol 33.23 100
water 33.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 332.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.05 mL 30.09 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ligneau et al (2007) Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. Biochem.Pharmacol. 73 1215 PMID: 17343831

Ligneau et al (2007) BF2.649 [1-{3-{3-(4-chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J.Pharm.Exp.Ther. 320 365 PMID:


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Keywords: BF2649 HCl histamine receptor H3 histaminergic antagonists inverse agonists nootropic Histamine H3 Receptors

Citations for BF 2649 hydrochloride

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