Betaxolol hydrochloride

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Cat.No. 0906 - Betaxolol hydrochloride | C18H29NO3.HCl | CAS No. 63659-19-8
Description: Selective β1 antagonist
Chemical Name: 1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanol hydrochloride
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity

Selective β1-adrenoceptor antagonist.

Technical Data

M. Wt 343.89
Formula C18H29NO3.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 63659-19-8
PubChem ID 107952

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 17.19 50

Preparing Stock Solutions

The following data is based on the product molecular weight 343.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.91 mL 14.54 mL 29.08 mL
5 mM 0.58 mL 2.91 mL 5.82 mL
10 mM 0.29 mL 1.45 mL 2.91 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Beresford and Heel (1986) Betaxolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in hypertension. Drugs 31 6 PMID: 2866947

Satoh et al (1993) The affinity of betaxolol, a β1-adrenoceptor-selective blocking agent, for β-adrenoceptors in the bovine trachea and heart Br.J.Pharmacol. 108 484 PMID: 8383566

Setoguchi et al (1995) Inhibitory action of betaxolol, a β1-selective adrenoceptor antagonist, on voltage-dependent calcium channels in guinea pig artery and vein. Br.J.Pharmacol. 115 198 PMID: 7647977

Merck Index 12 1229 PMID:

If you know of a relevant reference for Betaxolol hydrochloride, please let us know.

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2 Citations for Betaxolol hydrochloride

Citations are publications that use Tocris products. Selected citations for Betaxolol hydrochloride include:

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600

Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. Cardiovasc Res 355 183 PMID: 26306764

Do you know of a great paper that uses Betaxolol hydrochloride from Tocris? If so please let us know.

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