Betaxolol hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 0906 - Betaxolol hydrochloride | C18H29NO3.HCl | CAS No. 63659-19-8
Description: Selective β1 antagonist
Chemical Name: 1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Selective β1-adrenoceptor antagonist.

Technical Data

M. Wt 343.89
Formula C18H29NO3.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 63659-19-8
PubChem ID 107952
InChI Key CHDPSNLJFOQTRK-UHFFFAOYSA-N
Smiles Cl.CC(C)NCC(O)COC1=CC=C(CCOCC2CC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.19 50

Preparing Stock Solutions

The following data is based on the product molecular weight 343.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.91 mL 14.54 mL 29.08 mL
5 mM 0.58 mL 2.91 mL 5.82 mL
10 mM 0.29 mL 1.45 mL 2.91 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Beresford and Heel (1986) Betaxolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in hypertension. Drugs 31 6 PMID: 2866947

Satoh et al (1993) The affinity of betaxolol, a β1-adrenoceptor-selective blocking agent, for β-adrenoceptors in the bovine trachea and heart Br.J.Pharmacol. 108 484 PMID: 8383566

Setoguchi et al (1995) Inhibitory action of betaxolol, a β1-selective adrenoceptor antagonist, on voltage-dependent calcium channels in guinea pig artery and vein. Br.J.Pharmacol. 115 198 PMID: 7647977

Merck Index 12 1229 PMID:


If you know of a relevant reference for Betaxolol hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Adrenergic β1 Receptor Antagonists

Keywords: Selective α1-adrenoceptor beta1-adrenoceptor β1-Adrenergic beta1-Adrenergic b1-adrenoceptor b1-adrenergic antagonists receptors Adrenergic Beta-1 Receptors

2 Citations for Betaxolol hydrochloride

Citations are publications that use Tocris products. Selected citations for Betaxolol hydrochloride include:

Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. Cardiovasc Res 355 183 PMID: 26306764

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600


Do you know of a great paper that uses Betaxolol hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Pathways for Betaxolol hydrochloride

Protocols

TODO: Add Protocols