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Cat.No. 1956 - Bestatin | C16H24N2O4 | CAS No. 58970-76-6
Description: Aminopeptidase inhibitor
Alternative Names: Ubenimex
Chemical Name: N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine
Purity: ≥99% (HPLC)

Biological Activity

Aminopeptidase inhibitor (Ki = 0.001 - 90 mM); inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation.

Technical Data

M. Wt 308.38
Formula C16H24N2O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 58970-76-6
PubChem ID 72172
Smiles CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 15.42 50

Preparing Stock Solutions

The following data is based on the product molecular weight 308.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.21 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Imamura and Kimura (2000) Effect of ubenimex (Bestatin) on the cell growth and phenotype of HL-60 and HL-60R cell lines: up- and down-regulation of CD13/aminopeptidase N. Leuk.Lymphoma 37 663 PMID: 11042531

Scornik and Botbol (2001) Bestatin as an experimental tool in mammals. Curr.Drug Metab. 2 67 PMID: 11465152

Umezawa et al (1976) Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J.Antibiot. 29 97 PMID: 931798

If you know of a relevant reference for Bestatin, please let us know.

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Keywords: Bestatin, supplier, Aminopeptidase, inhibitors, inhibits, enkephalin, metabolism, leukotrienes, eicosanoids, A4, hydrolase, Proteases, Proteinases, Ubenimex, Aminopeptidases, LTA4, Hydrolase, Aminopeptidases, Tocris Bioscience

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