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Description: Aminopeptidase inhibitor
Alternative Names: Ubenimex
Chemical Name: N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine
Purity: ≥98% (HPLC)
Reviews (1)

Biological Activity for Bestatin

Bestatin is an aminopeptidase inhibitor (Ki = 0.001 - 90 mM); inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation.

Technical Data for Bestatin

M. Wt 308.38
Formula C16H24N2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 58970-76-6
PubChem ID 72172
Smiles CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bestatin

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 3.08 10

Preparing Stock Solutions for Bestatin

The following data is based on the product molecular weight 308.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.43 mL 162.14 mL 324.28 mL
0.5 mM 6.49 mL 32.43 mL 64.86 mL
1 mM 3.24 mL 16.21 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL

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Product Datasheets for Bestatin

Certificate of Analysis / Product Datasheet
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References for Bestatin

References are publications that support the biological activity of the product.

Imamura and Kimura (2000) Effect of ubenimex (Bestatin) on the cell growth and phenotype of HL-60 and HL-60R cell lines: up- and down-regulation of CD13/aminopeptidase N. Leuk.Lymphoma 37 663 PMID: 11042531

Scornik and Botbol (2001) Bestatin as an experimental tool in mammals. Curr.Drug Metab. 2 67 PMID: 11465152

Umezawa et al (1976) Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J.Antibiot. 29 97 PMID: 931798

If you know of a relevant reference for Bestatin, please let us know.

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Keywords: Bestatin, Bestatin supplier, Aminopeptidase, inhibitors, inhibits, enkephalin, metabolism, leukotrienes, eicosanoids, A4, hydrolase, Proteases, Proteinases, Ubenimex, Aminopeptidases, LTA4, Hydrolase, 1956, Tocris Bioscience

Citations for Bestatin

Citations are publications that use Tocris products.

Currently there are no citations for Bestatin. Do you know of a great paper that uses Bestatin from Tocris? Please let us know.

Reviews for Bestatin

Average Rating: 5 (Based on 1 Review.)

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Works well. Recommended..
By Anonymous on 05/14/2019
Assay Type: Ex Vivo
Species: Mouse

Used for slice electrophysiology work; bath applied with the opioid peptide dynorphin A to prevent its degradation with great results.

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