Benzoquinonium dibromide

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Cat.No. 0424 - Benzoquinonium dibromide | C34H50Br2N4O2 | CAS No. 311-09-1
Description: Nicotinic antagonist
Chemical Name: N,N'-[(3,6-Dioxo-1,4-cyclohexadiene-1,4-diyl)bis(imino-3,1-propanediyl)]bis[N,N-diethylbenzenemethanaminium]dibromide
Datasheet
Citations
Literature

Biological Activity

Nicotinic antagonist, ganglion blocker. Activates single channels but blocks open channels at nicotinic receptors.

Technical Data

M. Wt 706.6
Formula C34H50Br2N4O2
Storage Store at RT
CAS Number 311-09-1
PubChem ID 56972152
InChI Key DVQZHWAYOLXTHE-UHFFFAOYSA-N
Smiles [Br-].[Br-].CC[N+](CC)(CCCNC1=CC(=O)C(NCCC[N+](CC)(CC)CC2=CC=CC=C2)=CC1=O)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 70.66 100
water 3.53 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 706.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.42 mL 7.08 mL 14.15 mL
5 mM 0.28 mL 1.42 mL 2.83 mL
10 mM 0.14 mL 0.71 mL 1.42 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Bowman and Webb (1972) Neuromuscular blocking and ganglia blocking activities of some acetylcholine antagonists in the cat. J.Pharm.Pharmacol. 24 762 PMID: 4403972

Pereira et al (1993) Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons. J.Pharmacol.Exp.Ther. 265 1474 PMID: 8510023


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Keywords: Nicotinic antagonists Acetylcholine Receptors Non-Selective Subtypes nAChR Nicotinic Receptors (Non-selective)

Citations for Benzoquinonium dibromide

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Literature in this Area

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Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
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  • G-Protein-Coupled Receptors
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Nicotinic ACh Receptors

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

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Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for Benzoquinonium dibromide

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