Nicotinic antagonist, ganglion blocker. Activates single channels but blocks open channels at nicotinic receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||3.53||5mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 706.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.42 mL||7.08 mL||14.15 mL|
|5 mM||0.28 mL||1.42 mL||2.83 mL|
|10 mM||0.14 mL||0.71 mL||1.42 mL|
|50 mM||0.03 mL||0.14 mL||0.28 mL|
References are publications that support the products' biological activity.
Bowman and Webb (1972) Neuromuscular blocking and ganglia blocking activities of some acetylcholine antagonists in the cat. J.Pharm.Pharmacol. 24 762 PMID: 4403972
Pereira et al (1993) Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons. J.Pharmacol.Exp.Ther. 265 1474 PMID: 8510023
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Keywords: Benzoquinonium dibromide, supplier, Nicotinic, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience
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Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.