Benzoquinonium dibromide

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Cat.No. 0424 - Benzoquinonium dibromide | C34H50Br2N4O2
Description: nAChR antagonist
Chemical Name: N,N'-[(3,6-Dioxo-1,4-cyclohexadiene-1,4-diyl)bis(imino-3,1-propanediyl)]bis[N,N-diethylbenzenemethanaminium]dibromide
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Nicotinic antagonist, ganglion blocker. Activates single channels but blocks open channels at nicotinic receptors.

Technical Data

M. Wt 706.6
Formula C34H50Br2N4O2
Storage Store at RT
PubChem ID 56972152
InChI Key DVQZHWAYOLXTHE-UHFFFAOYSA-N
Smiles [Br-].[Br-].CC[N+](CC)(CCCNC1=CC(=O)C(NCCC[N+](CC)(CC)CC2=CC=CC=C2)=CC1=O)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 70.66 100
water 3.53 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 706.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.42 mL 7.08 mL 14.15 mL
5 mM 0.28 mL 1.42 mL 2.83 mL
10 mM 0.14 mL 0.71 mL 1.42 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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References

References are publications that support the biological activity of the product.

Bowman and Webb (1972) Neuromuscular blocking and ganglia blocking activities of some acetylcholine antagonists in the cat. J.Pharm.Pharmacol. 24 762 PMID: 4403972

Pereira et al (1993) Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons. J.Pharmacol.Exp.Ther. 265 1474 PMID: 8510023


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View all Nicotinic Receptor (Non-selective) Antagonists

Keywords: Benzoquinonium dibromide, Benzoquinonium dibromide supplier, Nicotinic, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, 311-09-1, (Non-selective), 0424, Tocris Bioscience

Citations for Benzoquinonium dibromide

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

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Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

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Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.