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Cat.No. 5420 - Benzbromarone | C17H12Br2O3 | CAS No. 3562-84-3
Description: TMEM16A/B calcium-activated chloride channel (CaCC) blocker
Chemical Name: (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)methanone
Purity: ≥99% (HPLC)

Biological Activity

TMEM16A/B calcium-activated chloride channel (CaCC) blocker. Inhibits ATP-induced mucin secretion and metacholine-induced airway smooth muscle contraction in vitro.

Technical Data

M. Wt 424.08
Formula C17H12Br2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 3562-84-3
PubChem ID 2333
Smiles O=C(C3=CC(Br)=C(O)C(Br)=C3)C2=C(CC)OC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.41 100
ethanol 8.48 20

Preparing Stock Solutions

The following data is based on the product molecular weight 424.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.79 mL 23.58 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References are publications that support the products' biological activity.

Huang et al (2012) Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc.Natl.Acad.Sci.U.S.A. 109 16354 PMID: 22988107

Gallos et al (2013) Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle. Am.J.Physiol.Lung Cell Mol.Physiol. 305 625 PMID: 23997176

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Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Benzbromarone


Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.