Benzbromarone

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Cat.No. 5420 - Benzbromarone | C17H12Br2O3 | CAS No. 3562-84-3
Description: TMEM16A/B calcium-activated chloride channel (CaCC) blocker
Chemical Name: (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)methanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature
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Biological Activity

TMEM16A/B calcium-activated chloride channel (CaCC) blocker. Inhibits ATP-induced mucin secretion and metacholine-induced airway smooth muscle contraction in vitro.

Technical Data

M. Wt 424.08
Formula C17H12Br2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 3562-84-3
PubChem ID 2333
InChI Key WHQCHUCQKNIQEC-UHFFFAOYSA-N
Smiles O=C(C3=CC(Br)=C(O)C(Br)=C3)C2=C(CC)OC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.41 100
ethanol 8.48 20

Preparing Stock Solutions

The following data is based on the product molecular weight 424.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.79 mL 23.58 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References

References are publications that support the biological activity of the product.

Huang et al (2012) Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc.Natl.Acad.Sci.U.S.A. 109 16354 PMID: 22988107

Gallos et al (2013) Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle. Am.J.Physiol.Lung Cell Mol.Physiol. 305 625 PMID: 23997176


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