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Biological Activity for Bendamustine hydrochloride
Bendamustine hydrochloride is a cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.
Technical Data for Bendamustine hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Bendamustine hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Bendamustine hydrochloride
The following data is based on the product molecular weight 394.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.53 mL||12.67 mL||25.33 mL|
|5 mM||0.51 mL||2.53 mL||5.07 mL|
|10 mM||0.25 mL||1.27 mL||2.53 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
Product Datasheets for Bendamustine hydrochloride
References for Bendamustine hydrochloride
References are publications that support the biological activity of the product.
Schwanen et al (2002) In vitro evaluation of bendamu. induced apoptosis in B-chronic lymphocytic leukemia. Leukemia. 16 2096 PMID: 12357363
Keating et al (2008) Bendamustine. Nat.Rev.Drug Discov. 7 473 PMID: 18511926
Masiello and Tulpule (2009) Bendamustine therapy in chronic lymphocytic leukemia. Expert Opin.Pharmacother. 10 1687 PMID: 19527193
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Citations for Bendamustine hydrochloride
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Reviews for Bendamustine hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Bendamustine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
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