Bendamustine hydrochloride
Biological Activity
Cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.
Technical Data
| M. Wt | 394.72 |
| Formula | C16H21Cl2N3O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 3543-75-7 |
| PubChem ID | 77082 |
| InChI Key | ZHSKUOZOLHMKEA-UHFFFAOYSA-N |
| Smiles | CN2C1=CC=C(N(CCCl)CCCl)C=C1N=C2CCCC(O)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.87 | 25 | |
| DMSO | 39.47 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 394.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.67 mL | 25.33 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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References
References are publications that support the biological activity of the product.
Schwanen et al (2002) In vitro evaluation of bendamustine induced apoptosis in B-chronic lymphocytic leukemia. Leukemia. 16 2096 PMID: 12357363
Keating et al (2008) Bendamustine. Nat.Rev.Drug Discov. 7 473 PMID: 18511926
Masiello and Tulpule (2009) Bendamustine therapy in chronic lymphocytic leukemia. Expert Opin.Pharmacother. 10 1687 PMID: 19527193
If you know of a relevant reference for Bendamustine hydrochloride, please let us know.
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Citations for Bendamustine hydrochloride
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Pathways for Bendamustine hydrochloride
