Bendamustine hydrochloride
Biological Activity
Cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.
Technical Data
| M. Wt | 394.72 |
| Formula | C16H21Cl2N3O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 3543-75-7 |
| PubChem ID | 77082 |
| InChI Key | ZHSKUOZOLHMKEA-UHFFFAOYSA-N |
| Smiles | CN2C1=CC=C(N(CCCl)CCCl)C=C1N=C2CCCC(O)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.47 | 100 | |
| ethanol | 39.47 | 100 | |
| water | 9.87 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 394.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.67 mL | 25.33 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Schwanen et al (2002) In vitro evaluation of bendamustine induced apoptosis in B-chronic lymphocytic leukemia. Leukemia. 16 2096 PMID: 12357363
Keating et al (2008) Bendamustine. Nat.Rev.Drug Discov. 7 473 PMID: 18511926
Masiello and Tulpule (2009) Bendamustine therapy in chronic lymphocytic leukemia. Expert Opin.Pharmacother. 10 1687 PMID: 19527193
If you know of a relevant reference for Bendamustine hydrochloride, please let us know.
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Keywords: Cytostatic agent exhibits DNA alkylating purine analogue properties apoptosis inducers dna synthesis inhibitors inhibits chemotherapeutics Apoptosis Inducers
Citations for Bendamustine hydrochloride
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Literature in this Area
Cancer Research Product Guide
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Bendamustine hydrochloride
