Bendamustine hydrochloride
Biological Activity
Cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.
Technical Data
| M. Wt | 394.72 |
| Formula | C16H21Cl2N3O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 3543-75-7 |
| PubChem ID | 77082 |
| InChI Key | ZHSKUOZOLHMKEA-UHFFFAOYSA-N |
| Smiles | CN2C1=CC=C(N(CCCl)CCCl)C=C1N=C2CCCC(O)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.87 | 25 | |
| DMSO | 39.47 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 394.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.67 mL | 25.33 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the biological activity of the product.
Schwanen et al (2002) In vitro evaluation of bendamustine induced apoptosis in B-chronic lymphocytic leukemia. Leukemia. 16 2096 PMID: 12357363
Keating et al (2008) Bendamustine. Nat.Rev.Drug Discov. 7 473 PMID: 18511926
Masiello and Tulpule (2009) Bendamustine therapy in chronic lymphocytic leukemia. Expert Opin.Pharmacother. 10 1687 PMID: 19527193
If you know of a relevant reference for Bendamustine hydrochloride, please let us know.
View Related Products by Target
Keywords: Bendamustine hydrochloride, Bendamustine hydrochloride supplier, Cytostatic, agent, exhibits, DNA, alkylating, purine, analogue, properties, apoptosis, inducers, dna, synthesis, inhibitors, inhibits, chemotherapeutics, Apoptosis, Inducers, DNA,, RNA, and, Protein, Synthesis, 3681, Tocris Bioscience
Citations for Bendamustine hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Bendamustine hydrochloride. Do you know of a great paper that uses Bendamustine hydrochloride from Tocris? Please let us know.
Reviews for Bendamustine hydrochloride
There are currently no reviews for this product. Be the first to review Bendamustine hydrochloride and earn rewards!
Have you used Bendamustine hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Bendamustine hydrochloride
