Bendamustine hydrochloride

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Cat.No. 3681 - Bendamustine hydrochloride | C16H21Cl2N3O2.HCl | CAS No. 3543-75-7
Description: Cytostatic agent; exhibits DNA alkylating and purine analog properties
Chemical Name: 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.

Technical Data

M. Wt 394.72
Formula C16H21Cl2N3O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 3543-75-7
PubChem ID 77082
InChI Key ZHSKUOZOLHMKEA-UHFFFAOYSA-N
Smiles CN2C1=CC=C(N(CCCl)CCCl)C=C1N=C2CCCC(O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.87 25
DMSO 39.47 100

Preparing Stock Solutions

The following data is based on the product molecular weight 394.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.67 mL 25.33 mL
5 mM 0.51 mL 2.53 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References

References are publications that support the biological activity of the product.

Schwanen et al (2002) In vitro evaluation of bendamustine induced apoptosis in B-chronic lymphocytic leukemia. Leukemia. 16 2096 PMID: 12357363

Keating et al (2008) Bendamustine. Nat.Rev.Drug Discov. 7 473 PMID: 18511926

Masiello and Tulpule (2009) Bendamustine therapy in chronic lymphocytic leukemia. Expert Opin.Pharmacother. 10 1687 PMID: 19527193


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Citations for Bendamustine hydrochloride

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Literature in this Area

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Cancer

Cancer Research Product Guide

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Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Bendamustine hydrochloride

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.