Home / Cell Biology / Regulated Cell Death / Apoptosis / Apoptosis Inducers / Bendamustine hydrochloride

Bendamustine hydrochloride

Cat. No. 3681 1 Review Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 3681 - Bendamustine hydrochloride | C16H21Cl2N3O2.HCl | CAS No. 3543-75-7
Description: Cytostatic agent; exhibits DNA alkylating and purine analog properties
Chemical Name: 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Bendamustine hydrochloride

Bendamustine hydrochloride is a cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.

Technical Data for Bendamustine hydrochloride

M. Wt 394.72
Formula C16H21Cl2N3O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 3543-75-7
PubChem ID 77082
InChI Key ZHSKUOZOLHMKEA-UHFFFAOYSA-N
Smiles CN2C1=CC=C(N(CCCl)CCCl)C=C1N=C2CCCC(O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bendamustine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.87 25
DMSO 39.47 100

Preparing Stock Solutions for Bendamustine hydrochloride

The following data is based on the product molecular weight 394.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.67 mL 25.33 mL
5 mM 0.51 mL 2.53 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Bendamustine hydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Bendamustine hydrochloride

References are publications that support the biological activity of the product.

Schwanen et al (2002) In vitro evaluation of bendamu. induced apoptosis in B-chronic lymphocytic leukemia. Leukemia. 16 2096 PMID: 12357363

Keating et al (2008) Bendamustine. Nat.Rev.Drug Discov. 7 473 PMID: 18511926

Masiello and Tulpule (2009) Bendamustine therapy in chronic lymphocytic leukemia. Expert Opin.Pharmacother. 10 1687 PMID: 19527193

If you know of a relevant reference for Bendamustine hydrochloride, please let us know.

View Related Products by Target

Keywords: Bendamustine hydrochloride, Bendamustine hydrochloride supplier, Cytostatic, agent, exhibits, DNA, alkylating, purine, analogue, properties, apoptosis, inducers, dna, synthesis, inhibitors, inhibits, chemotherapeutics, Apoptosis, Inducers, DNA,, RNA, and, Protein, Synthesis, 3681, Tocris Bioscience

Citations for Bendamustine hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Bendamustine hydrochloride. Do you know of a great paper that uses Bendamustine hydrochloride from Tocris? Please let us know.

Reviews for Bendamustine hydrochloride

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Bendamustine hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Bendamustine termporarily halts growth of melanoma cells in vitro.
By Anonymous on 02/14/2019
Assay Type: In Vitro
Species: Human

Bendamustine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Bendamustine hydrochloride

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.