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Submit ReviewBendamustine hydrochloride
Description: Cytostatic agent; exhibits DNA alkylating and purine analog properties
Chemical Name: 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Bendamustine hydrochloride
Bendamustine hydrochloride is a cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.
Technical Data for Bendamustine hydrochloride
| M. Wt | 394.72 |
| Formula | C16H21Cl2N3O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 3543-75-7 |
| PubChem ID | 77082 |
| InChI Key | ZHSKUOZOLHMKEA-UHFFFAOYSA-N |
| Smiles | CN2C1=CC=C(N(CCCl)CCCl)C=C1N=C2CCCC(O)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Bendamustine hydrochloride
References for Bendamustine hydrochloride
References are publications that support the biological activity of the product.
Schwanen et al (2002) In vitro evaluation of bendamu. induced apoptosis in B-chronic lymphocytic leukemia. Leukemia. 16 2096 PMID: 12357363
Keating et al (2008) Bendamustine. Nat.Rev.Drug Discov. 7 473 PMID: 18511926
Masiello and Tulpule (2009) Bendamustine therapy in chronic lymphocytic leukemia. Expert Opin.Pharmacother. 10 1687 PMID: 19527193
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Citations for Bendamustine hydrochloride
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Currently there are no citations for Bendamustine hydrochloride.
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Bendamustine termporarily halts growth of melanoma cells in vitro.
By
Anonymous on 02/14/2019
Assay Type: In Vitro
Species: Human
Bendamustine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
Literature in this Area
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Bendamustine hydrochloride
