Benazepril hydrochloride

Pricing Availability   Qty
Description: Angiotensin-converting enzyme (ACE) inhibitor
Alternative Names: CGS 14824A
Chemical Name: (3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride
Purity: ≥99% (HPLC)
Citations (3)
Literature (1)

Biological Activity for Benazepril hydrochloride

Benazepril hydrochloride is a non-peptide angiotensin-converting enzyme (ACE) inhibitor. Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.

Compound Libraries for Benazepril hydrochloride

Benazepril hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Benazepril hydrochloride

M. Wt 460.96
Formula C24H28N2O5.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 86541-74-4
PubChem ID 5362123
Smiles O=[C@@](OCC)[C@H](CCC3=CC=CC=C3)N[C@H]1CCC2=C(C=CC=C2)N(CC(O)=O)C1=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Benazepril hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 23.05 50
DMSO 46.1 100

Preparing Stock Solutions for Benazepril hydrochloride

The following data is based on the product molecular weight 460.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.85 mL 21.69 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets for Benazepril hydrochloride

Certificate of Analysis / Product Datasheet
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References for Benazepril hydrochloride

References are publications that support the biological activity of the product.

Takemori et al (1991) Effect of benaz. hydrochloride on cardiac hypertrophy in spontaneous hypertensive rats. Arzneim.-Forsch. 41 612

Ishibashi et al (1991) Hemodynamic effects of benazepril, an angiotensin-converting enzyme inhibitor, as studied in conscious normotensive dogs. Cardiovas.Drugs Ther. 5 635

Yamamoto et al (1991) General pharmacology of the novel angiotensin converting enzyme inhibitor benaz. hydrochloride. Effects on cardiovascular, visceral and renal functions and on hemodynamics. Arzneim.-Forsch. 41 913

If you know of a relevant reference for Benazepril hydrochloride, please let us know.

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3 Citations for Benazepril hydrochloride

Citations are publications that use Tocris products. Selected citations for Benazepril hydrochloride include:

Li et al (2018) Characterization of UDP-Activated Purinergic Receptor P2Y6 Involved in Japanese Flounder Paralichthys olivaceus Innate Immunity. Int J Mol Sci 19 PMID: 30029501

Bulavina et al (2013) NTPDase1 activity attenuates microglial phagocytosis. Purinergic Signal 9 199 PMID: 23208703

Deng et al (2017) Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture. J Pharmacol Exp Ther 360 215 PMID: 27821713

Do you know of a great paper that uses Benazepril hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure