Benazepril hydrochloride

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Cat.No. 2578 - Benazepril hydrochloride | C24H28N2O5.HCl | CAS No. 86541-74-4
Description: Angiotensin-converting enzyme (ACE) inhibitor
Alternative Names: CGS 14824A
Chemical Name: (3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)

Biological Activity

Non-peptide angiotensin-converting enzyme (ACE) inhibitor. Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.

Compound Libraries

Benazepril hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 460.96
Formula C24H28N2O5.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 86541-74-4
PubChem ID 5362123
InChI Key VPSRQEHTHIMDQM-FKLPMGAJSA-N
Smiles O=[C@@](OCC)[C@H](CCC3=CC=CC=C3)N[C@H]1CCC2=C(C=CC=C2)N(CC(O)=O)C1=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.05 50
DMSO 46.1 100

Preparing Stock Solutions

The following data is based on the product molecular weight 460.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.85 mL 21.69 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Takemori et al (1991) Effect of benaz. hydrochloride on cardiac hypertrophy in spontaneous hypertensive rats. Arzneim.-Forsch. 41 612

Ishibashi et al (1991) Hemodynamic effects of benazepril, an angiotensin-converting enzyme inhibitor, as studied in conscious normotensive dogs. Cardiovas.Drugs Ther. 5 635

Yamamoto et al (1991) General pharmacology of the novel angiotensin converting enzyme inhibitor benaz. hydrochloride. Effects on cardiovascular, visceral and renal functions and on hemodynamics. Arzneim.-Forsch. 41 913


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3 Citations for Benazepril hydrochloride

Citations are publications that use Tocris products. Selected citations for Benazepril hydrochloride include:

Deng et al (2017) Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture. J Pharmacol Exp Ther 360 215 PMID: 27821713

Bulavina et al (2013) NTPDase1 activity attenuates microglial phagocytosis. Purinergic Signal 9 199 PMID: 23208703

Li et al (2018) Characterization of UDP-Activated Purinergic Receptor P2Y6 Involved in Japanese Flounder Paralichthys olivaceus Innate Immunity. Int J Mol Sci 19 PMID: 30029501


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Literature in this Area

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Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure