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BDY FL Thalidomide New
Biological Activity for BDY FL Thalidomide
BDY FL Thalidomide is a high-affinity fluorescent probe (Kd = 3.6 nM). It can be used in time-resolved fluorescence resonance energy-transfer (TR-FRET) cereblon binding assays for PROTAC® Degrader development. This assay is highly sensitive, selective, and stable. Excitation and emission maxima (λ) are 502 and 510 nm, respectively.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Optical Data for BDY FL Thalidomide
|Closest Laser line||488 nm|
|Application||Time-resolved fluorescence energy transfer (TR-FRET)|
|Alternative For||FAM; Alexa Fluor 488; DyLight 488; Cy2|
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company.
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.Spectral Viewer
Technical Data for BDY FL Thalidomide
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BDY FL Thalidomide
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BDY FL Thalidomide
The following data is based on the product molecular weight 732.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||13.65 mL||68.25 mL||136.5 mL|
|0.5 mM||2.73 mL||13.65 mL||27.3 mL|
|1 mM||1.37 mL||6.83 mL||13.65 mL|
|5 mM||0.27 mL||1.37 mL||2.73 mL|
Product Datasheets for BDY FL Thalidomide
References for BDY FL Thalidomide
References are publications that support the biological activity of the product.
Lin et al (2021) General stepwise approach to optimize a TR-FRET assay for characterizing the BRD/PROTAC/CRBN ternary complex. ACS Pharmacol.Transl.Sci. 4 941 PMID: 33860212
Lin et al (2020) Development of BODIPY FL Thalidomide as a high-affinity fluorescent probe for cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer assay. Bioconjug.Chem. 31 2564 PMID: 33070611
If you know of a relevant reference for BDY FL Thalidomide, please let us know.
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Citations for BDY FL Thalidomide
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Fluorescent Dyes and Probes Research Product Guide
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