BAY-X 1005

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Cat.No. 3541 - BAY-X 1005 | C23H23NO3 | CAS No. 128253-31-6
Description: Orally active 5-lipoxygenase activating protein (FLAP) inhibitor
Chemical Name: (R)-α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

5-lipoxygenase activating protein (FLAP) inhibitor. Inhibits the synthesis of leukotrienes B4 and C4 in animal models; inhibits synthesis of leukotriene B4 in A23187-stimulated leukocytes (IC50 values are 0.026, 0.039 and 0.22 μM for rat, mice and human leukocytes respectively). Displays anti-inflammatory activity. Orally active.

Technical Data

M. Wt 361.43
Formula C23H23NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 128253-31-6
PubChem ID 123723
InChI Key ZEYYDOLCHFETHQ-JOCHJYFZSA-N
Smiles O=[C@@]([C@H](C4CCCC4)C(C=C3)=CC=C3OCC2=NC1=CC=CC=C1C=C2)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 361.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.83 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References

References are publications that support the biological activity of the product.

Muller-Peddinghaus et al (1993) BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. J.Pharmacol.Exp.Ther. 267 51 PMID: 8229782

Hatzelmann et al (1994) Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: implications for biological regulation of 5-lipoxygenase. Agents Actions 43 64 PMID: 7741044

Fruchtmann et al (1993) In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis. Agents Actions 38 188 PMID: 8213345


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Citations for BAY-X 1005

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