BAY 826

Pricing Availability   Qty
Description: Potent Tie2 inhibitor
Chemical Name: [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for BAY 826

BAY 826 is a potent Tie 2 inhibitor (IC50 = 1.3 nM for autophosphorylation of Tie2 in HUVECs), which is selective for Tie2 over other angiogenic receptor tyrosine kinases, including VEGFR, FGFR and PDGFR. BAY 826 displays in vivo efficacy in some murine glioma models.

Tie2 is also known as angiopoietin-1 receptor and TEK tyrosine kinase.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-826 probe summary on the SGC website.

External Portal Information for BAY 826 is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 826 is reviewed on the chemical probes website.

Compound Libraries for BAY 826

BAY 826 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for BAY 826

M. Wt 558.53
Formula C26H19F5N6OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1448316-08-2
PubChem ID 71623052
Smiles CC1=CC(C)=C(C=C1N2C=CN3N=C(C4=CN=CC=C4)C=C23)NC(C5=CC(S(F)(F)(F)(F)F)=CC(C#N)=C5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 826

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 100
ethanol 100

Preparing Stock Solutions for BAY 826

The following data is based on the product molecular weight 558.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.79 mL 8.95 mL 17.9 mL
5 mM 0.36 mL 1.79 mL 3.58 mL
10 mM 0.18 mL 0.9 mL 1.79 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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References for BAY 826

References are publications that support the biological activity of the product.

Schneider et al (2017) Novel TIE-2 inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models. J.Neurochem. 140 170 PMID: 27787897

If you know of a relevant reference for BAY 826, please let us know.

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Keywords: BAY 826, BAY 826 supplier, BAY826, TEK, tyrosine, kinase, Tie, 2, angiopoietin, 1, receptor, inhibitors, inhibits, Other, RTKs, 6579, Tocris Bioscience

1 Citation for BAY 826

Citations are publications that use Tocris products. Selected citations for BAY 826 include:

Stephanie et al (2022) Angiopoietin-1 Upregulates Cancer Cell Motility in Colorectal Cancer Liver Metastases through Actin-Related Protein 2/3. Cancers (Basel) 14 PMID: 35626145

Do you know of a great paper that uses BAY 826 from Tocris? Please let us know.

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