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BAY 826 is a potent Tie 2 inhibitor (IC50 = 1.3 nM for autophosphorylation of Tie2 in HUVECs), which is selective for Tie2 over other angiogenic receptor tyrosine kinases, including VEGFR, FGFR and PDGFR. BAY 826 displays in vivo efficacy in some murine glioma models.
Tie2 is also known as angiopoietin-1 receptor and TEK tyrosine kinase.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-826 probe summary on the SGC website.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 826 is reviewed on the chemical probes website.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 558.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.79 mL||8.95 mL||17.9 mL|
|5 mM||0.36 mL||1.79 mL||3.58 mL|
|10 mM||0.18 mL||0.9 mL||1.79 mL|
|50 mM||0.04 mL||0.18 mL||0.36 mL|
References are publications that support the biological activity of the product.
Schneider et al (2017) Novel TIE-2 inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models. J.Neurochem. 140 170 PMID: 27787897
If you know of a relevant reference for BAY 826, please let us know.
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Keywords: BAY 826, BAY 826 supplier, BAY826, TEK, tyrosine, kinase, Tie, 2, angiopoietin, 1, receptor, inhibitors, inhibits, Other, RTKs, 6579, Tocris Bioscience
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