You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for BAY 826
BAY 826 is a potent Tie 2 inhibitor (IC50 = 1.3 nM for autophosphorylation of Tie2 in HUVECs), which is selective for Tie2 over other angiogenic receptor tyrosine kinases, including VEGFR, FGFR and PDGFR. BAY 826 displays in vivo efficacy in some murine glioma models.
Tie2 is also known as angiopoietin-1 receptor and TEK tyrosine kinase.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-826 probe summary on the SGC website.
External Portal Information for BAY 826
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 826 is reviewed on the chemical probes website.
Compound Libraries for BAY 826
Technical Data for BAY 826
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BAY 826
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BAY 826
The following data is based on the product molecular weight 558.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.79 mL||8.95 mL||17.9 mL|
|5 mM||0.36 mL||1.79 mL||3.58 mL|
|10 mM||0.18 mL||0.9 mL||1.79 mL|
|50 mM||0.04 mL||0.18 mL||0.36 mL|
References for BAY 826
References are publications that support the biological activity of the product.
Schneider et al (2017) Novel TIE-2 inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models. J.Neurochem. 140 170 PMID: 27787897
If you know of a relevant reference for BAY 826, please let us know.
View Related Products by Product Action
Keywords: BAY 826, BAY 826 supplier, BAY826, TEK, tyrosine, kinase, Tie, 2, angiopoietin, 1, receptor, inhibitors, inhibits, Other, RTKs, 6579, Tocris Bioscience
Citations for BAY 826
Citations are publications that use Tocris products.
Currently there are no citations for BAY 826. Do you know of a great paper that uses BAY 826 from Tocris? Please let us know.
Reviews for BAY 826
There are currently no reviews for this product. Be the first to review BAY 826 and earn rewards!
Have you used BAY 826?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.