BAY 677

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Cat.No. 6389 - BAY 677 | C20H15F3N4O2 | CAS No. 2117404-84-7
Description: Inactive control for BAY 678 (Cat.No.5706)
Chemical Name: 5-[(4S)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
Purity: ≥98% (HPLC)

Biological Activity

Inactive control for BAY 678 (Cat.No.5706).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 678 probe summary on the SGC website.

Technical Data

M. Wt 400.35
Formula C20H15F3N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2117404-84-7
Smiles CC(C1=C(N(C2=CC(C(F)(F)F)=CC=C2)C(N[C@H]1C3=CN=C(C#N)C=C3)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 400.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.49 mL 24.98 mL
5 mM 0.5 mL 2.5 mL 5 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

von Nussbaum et al (2015) Freezing the bioactive conformation to boost potency: The identification of BAY 85-8501, a selective and potent inhibitor of human neutrophil elastase for pulmonary diseases. ChemMedChem 10 1163 PMID: 26083237

If you know of a relevant reference for BAY 677, please let us know.

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Keywords: BAY 677, supplier, BAY677, human, neutrophil, elastase, HNE, negative, control, s-enantiomer, Elastase, Elastase, Tocris Bioscience

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