BAY 677

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Description: Inactive control for BAY 678 (Cat.No.5706)
Chemical Name: 5-[(4S)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
Purity: ≥98% (HPLC)

Biological Activity for BAY 677

BAY 677 is an inactive control for BAY 678 (Cat.No.5706).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 678 probe summary on the SGC website.

Technical Data for BAY 677

M. Wt 400.35
Formula C20H15F3N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2117404-84-7
PubChem ID 68944900
Smiles CC(C1=C(N(C2=CC(C(F)(F)F)=CC=C2)C(N[C@H]1C3=CN=C(C#N)C=C3)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 677

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.03 100

Preparing Stock Solutions for BAY 677

The following data is based on the product molecular weight 400.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.49 mL 24.98 mL
5 mM 0.5 mL 2.5 mL 5 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for BAY 677

References are publications that support the biological activity of the product.

von Nussbaum et al (2015) Freezing the bioactive conformation to boost potency: The identification of BAY 85-8501, a selective and potent inhibitor of human neutrophil elastase for pulmonary diseases. ChemMedChem 10 1163 PMID: 26083237

If you know of a relevant reference for BAY 677, please let us know.

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Citations for BAY 677

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