BAY 6035

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Cat.No. 6561 - BAY 6035 | C22H28N4O3 | CAS No. 2247890-13-5
Description: Potent and selective SMYD3 inhibitor
Chemical Name: (2S)-1-(3-Azabicyclo[3.1.0]hex-3-ylcarbonyl)-N-(2-cyclopropylethyl)-2,3,4,5-tetrahydro-2-methyl-4-oxo-1H-1,5-benzodiazepine-7-carboxamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Potent SMYD3 inhibitor (IC50 = 70 nM for inhibition of MEKK2 methylation in cells). Exhibits >100-fold selectivity for SMYD3 over other histone methyltransferases.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-6035 probe summary on the SGC website.

Technical Data

M. Wt 396.48
Formula C22H28N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2247890-13-5
PubChem ID 137499231
Smiles O=C(NCCC1CC1)C2=CC=C3N([C@H](CC(NC3=C2)=O)C)C(N4CC5CC5C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.65 100
ethanol 39.65 100

Preparing Stock Solutions

The following data is based on the product molecular weight 396.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.61 mL 25.22 mL
5 mM 0.5 mL 2.52 mL 5.04 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References are publications that support the biological activity of the product.

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Citations for BAY 6035

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Literature in this Area

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