Bay 36-7620

Pricing Availability   Qty
Description: mGlu1 inverse agonist
Chemical Name: (3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one
Purity: ≥98% (HPLC)
Citations (9)
Literature (5)

Biological Activity for Bay 36-7620

Bay 36-7620 is a selective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.

Licensing Information

Sold for research purposes under agreement from Bayer

Technical Data for Bay 36-7620

M. Wt 278.35
Formula C19H18O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 232605-26-4
PubChem ID 9903757
Smiles C=C1C[C@@]2([H])[C@@](C(OC2)=O)(CC3=CC(C=CC=C4)=C4C=C3)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bay 36-7620

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.84 100
ethanol 27.84 100

Preparing Stock Solutions for Bay 36-7620

The following data is based on the product molecular weight 278.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.59 mL 17.96 mL 35.93 mL
5 mM 0.72 mL 3.59 mL 7.19 mL
10 mM 0.36 mL 1.8 mL 3.59 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets for Bay 36-7620

Certificate of Analysis / Product Datasheet
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References for Bay 36-7620

References are publications that support the biological activity of the product.

Carroll et al (2001) BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Mol.Pharmacol. 59 965 PMID: 11306677

De Vry et al (2001) Neuroprotective and behavioural effects of the selective metabotropic glutamate mGlu1 receptor antagonist BAY 36-7620. Eur.J.Pharmacol. 428 203 PMID: 11675037

Gil-Sanz et al (2007) Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice. Cereb.Cortex 18 1653 PMID: 18024992

If you know of a relevant reference for Bay 36-7620, please let us know.

Keywords: Bay 36-7620, Bay 36-7620 supplier, Bay367620, selective, non-competitive, mGlu1, mGluR1, antagonists, receptors, inverse, agonists, metabotropic, glutamate, Glutamate, (Metabotropic), Group, I, Receptors, 2501, Tocris Bioscience

9 Citations for Bay 36-7620

Citations are publications that use Tocris products. Selected citations for Bay 36-7620 include:

Dolfi et al (2017) R.zole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells. Oncotarget 8 44639 PMID: 28591718

Speyer et al (2012) Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer. Breast Cancer Res Treat 132 565 PMID: 21681448

Foong (2009) mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig Ileum. Front Neurosci 3 46 PMID: 20582273

Le et al (2010) The glutamate release inhibitor R.zole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol 130 2240 PMID: 20505744

Do you know of a great paper that uses Bay 36-7620 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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