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BAY 091 New
Biological Activity for BAY 091
BAY 091 is a potent and selective, ATP-dependent, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) inhibitor (IC50 values are 1.3 nM, 8.5 nM and 16.4 nM with 10 μM ATP, or in an HTRF assay with 10 μM and 2 mM ATP, respectively).
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 091 probe summary on the SGC website.
Technical Data for BAY 091
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BAY 091
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||22.02||50 with gentle warming|
Preparing Stock Solutions for BAY 091
The following data is based on the product molecular weight 440.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.54 mL||22.7 mL||45.41 mL|
|2.5 mM||0.91 mL||4.54 mL||9.08 mL|
|5 mM||0.45 mL||2.27 mL||4.54 mL|
|25 mM||0.09 mL||0.45 mL||0.91 mL|
References for BAY 091
References are publications that support the biological activity of the product.
Wortmann et al (2021) Discovery and characterization of the potent and highly selective 1,7-naphthyridine-based inhibitors BAY-091 and BAY-297 of the kinase PIP4K2A. J.Med.Chem. 64 15883 PMID: 34699202
If you know of a relevant reference for BAY 091, please let us know.
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Citations for BAY 091
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Literature in this Area
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