Discontinued Product

BAM 22P (Cat. No. 1650) has been withdrawn from sale for commercial reasons.
Description: MRGPRX1 agonist; also opioid receptor agonist
Alternative Names: Bovine adrenal medullary peptide-22P,BAM 22 (1-22)
Citations (1)

Biological Activity for BAM 22P

Potent endogenous agonist peptide for Mas-related G proteins-coupled receptor X1 (MRGPRX1); isolated from bovine adrenal medulla (EC50 values are 16 - 800 nM) Also potent opioid agonist (IC50 = 1.3 nM in guinea pig ileum preparation). Produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo.

Technical Data for BAM 22P

M. Wt 2839.24
Formula C130H184N38O31S2
Storage Desiccate at -20°C
CAS Number 76622-26-9
PubChem ID 16132339
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for BAM 22P

Certificate of Analysis / Product Datasheet
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References for BAM 22P

References are publications that support the biological activity of the product.

Hong et al (2004) Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor. Br.J.Pharmacol. 141 423 PMID: 14718254

Lembo et al (2002) Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 5 201 PMID: 11850634

Mizuno et al (1980) A new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem.Biophys.Res.Commun. 97 1283 PMID: 7213356

Simonin and Kieffer (2002) Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 5 185 PMID: 11865303

Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890

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Keywords: BAM 22P, BAM 22P supplier, agonists, sensory, neuron-specific, receptors, SNSR, Opioids, BAM22P, BAM22(1-22), agonism, mas-related, g, protein-coupled, MRGPRX1, Bovine, adrenal, medullary, peptide-22P, BAM, 22, (1-22), Miscellaneous/Non-selective, Mas-related, G, Protein-Coupled, Receptors, 1650, Tocris Bioscience

1 Citation for BAM 22P

Citations are publications that use Tocris products. Selected citations for BAM 22P include:

Gupta et al (2014) Opioid receptor function is regulated by post-endocytic peptide processing. J Biol Chem 289 19613 PMID: 24847082

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