You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent endogenous agonist peptide for Mas-related G proteins-coupled receptor X1 (MRGPRX1); isolated from bovine adrenal medulla (EC50 values are 16 - 800 nM) Also potent opioid agonist (IC50 = 1.3 nM in guinea pig ileum preparation). Produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Hong et al (2004) Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor. Br.J.Pharmacol. 141 423 PMID: 14718254
Lembo et al (2002) Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 5 201 PMID: 11850634
Mizuno et al (1980) A new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem.Biophys.Res.Commun. 97 1283 PMID: 7213356
Simonin and Kieffer (2002) Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 5 185 PMID: 11865303
Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890
If you know of a relevant reference for BAM 22P, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: BAM 22P, BAM 22P supplier, agonists, sensory, neuron-specific, receptors, SNSR, Opioids, BAM22P, BAM22(1-22), agonism, mas-related, g, protein-coupled, MRGPRX1, Bovine, adrenal, medullary, peptide-22P, BAM, 22, (1-22), Miscellaneous/Non-selective, Mas-related, G, Protein-Coupled, Receptors, 1650, Tocris Bioscience
1 Citation for BAM 22P
Citations are publications that use Tocris products. Selected citations for BAM 22P include:
Gupta et al (2014) Opioid receptor function is regulated by post-endocytic peptide processing. J Biol Chem 289 19613 PMID: 24847082
Do you know of a great paper that uses BAM 22P from Tocris? Please let us know.
Reviews for BAM 22P
There are currently no reviews for this product. Be the first to review BAM 22P and earn rewards!
Have you used BAM 22P?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.