Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR); isolated from bovine adrenal medulla. EC50 values are 13 and 16 nM for human SNSR3 and SNSR4 respectively. Also potent opioid agonist (IC50 = 1.3 nM in guinea pig ileum preparation). Produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 2839.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.35 mL||1.76 mL||3.52 mL|
|5 mM||0.07 mL||0.35 mL||0.7 mL|
|10 mM||0.04 mL||0.18 mL||0.35 mL|
|50 mM||0.01 mL||0.04 mL||0.07 mL|
References are publications that support the products' biological activity.
Hong et al (2004) Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor. Br.J.Pharmacol. 141 423 PMID: 14718254
Lembo et al (2002) Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 5 201 PMID: 11850634
Mizuno et al (1980) A new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem.Biophys.Res.Commun. 97 1283 PMID: 7213356
Simonin and Kieffer (2002) Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 5 185 PMID: 11865303
If you know of a relevant reference for BAM 22P, please let us know.
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Keywords: BAM 22P, supplier, agonists, sensory, neuron-specific, receptors, SNSR, Opioids, BAM22P, BAM22(1-22), Bovine, adrenal, medullary, peptide-22P, BAM, 22, (1-22), Miscellaneous/Non-selective, Opioids, Sensory, Neuron-Specific, Receptors, Miscellaneous/Non-selective, Opioids, Tocris Bioscience
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