β-Pompilidotoxin

Discontinued Product

β-Pompilidotoxin (Cat. No. 1539) has been withdrawn from sale for commercial reasons.
Description: Slows neuronal Na+ channel inactivation
Alternative Names: β-PMTX
Datasheet
Citations
Reviews

Biological Activity for β-Pompilidotoxin

β-Pompilidotoxin is a novel wasp neurotoxin that slows Na+ channel inactivation. Facilitates neuromuscular synaptic transmission and discriminates between rat neuronal and cardiac Na+ channel α-subunits.

Licensing Information

Sold with the permission of Suntory Ltd.

Technical Data for β-Pompilidotoxin

M. Wt 1557.9
Formula C71H124N22O17
Sequence RIKIGLFDQLSRL

(Modifications: Leu-13 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 216064-36-7
PubChem ID 90479801
InChI Key YBOJYGJMKPMNRC-QRIWDNSUSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for β-Pompilidotoxin

Certificate of Analysis / Product Datasheet
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References for β-Pompilidotoxin

References are publications that support the biological activity of the product.

Kinoshita et al (2001) Novel wasp toxin discriminates between neuronal and cardiac sodium channels. Mol.Pharmacol. 59 1457 PMID: 11353806

Konno et al (1998) Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms. Biochem.Biophys.Res.Commun. 250 612 PMID: 9784394

Miyawaki et al (2002) Differential effects of novel wasp toxin on rat hippocampal interneurons. Neurosci.Lett. 328 25 PMID: 12123851

Keywords: beta-Pompilidotoxin, beta-Pompilidotoxin supplier, Slows, neuronal, Na+, channels, inactivation, Sodium, NaV, voltage-gated, voltage-dependent, beta-Pompilidotoxin, β-PMTX, beta-PMTX, neurotoxins, venoms, b-PMTX, Voltage-gated, Channels, 1539, Tocris Bioscience

Citations for β-Pompilidotoxin

Citations are publications that use Tocris products.

Currently there are no citations for β-Pompilidotoxin.

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