β-Pompilidotoxin

Pricing Availability Delivery Time Qty
Cat.No. 1539 - beta-Pompilidotoxin | Arg-Ile-Lys-Ile-Gly-Leu-Phe-Asp-Gln-Leu-Ser-Arg-Leu-NH2 | CAS No. 216064-36-7
Description: Slows neuronal Na+ channel inactivation
Alternative Names: β-PMTX
Datasheet
Citations
Reviews
Literature

Biological Activity

Novel wasp neurotoxin that slows Na+ channel inactivation. Facilitates neuromuscular synaptic transmission and discriminates between rat neuronal and cardiac Na+ channel α-subunits.

Licensing Information

Sold with the permission of Suntory Ltd.

Technical Data

M. Wt 1557.9
Formula C71H124N22O17
Sequence RIKIGLFDQLSRL

(Modifications: Leu-13 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 216064-36-7
PubChem ID 90479801
InChI Key YBOJYGJMKPMNRC-QRIWDNSUSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1557.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.64 mL 3.21 mL 6.42 mL
5 mM 0.13 mL 0.64 mL 1.28 mL
10 mM 0.06 mL 0.32 mL 0.64 mL
50 mM 0.01 mL 0.06 mL 0.13 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Kinoshita et al (2001) Novel wasp toxin discriminates between neuronal and cardiac sodium channels. Mol.Pharmacol. 59 1457 PMID: 11353806

Konno et al (1998) Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms. Biochem.Biophys.Res.Commun. 250 612 PMID: 9784394

Miyawaki et al (2002) Differential effects of novel wasp toxin on rat hippocampal interneurons. Neurosci.Lett. 328 25 PMID: 12123851


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Keywords: beta-Pompilidotoxin, beta-Pompilidotoxin supplier, Slows, neuronal, Na+, channels, inactivation, Sodium, NaV, voltage-gated, voltage-dependent, beta-Pompilidotoxin, β-PMTX, beta-PMTX, neurotoxins, venoms, b-PMTX, Voltage-gated, Channels, 1539, Tocris Bioscience

Citations for β-Pompilidotoxin

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Literature in this Area

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