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Submit Reviewβ-Pompilidotoxin is a novel wasp neurotoxin that slows Na+ channel inactivation. Facilitates neuromuscular synaptic transmission and discriminates between rat neuronal and cardiac Na+ channel α-subunits.
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M. Wt | 1557.9 |
Formula | C71H124N22O17 |
Sequence |
RIKIGLFDQLSRL (Modifications: Leu-13 = C-terminal amide) |
Storage | Desiccate at -20°C |
CAS Number | 216064-36-7 |
PubChem ID | 90479801 |
InChI Key | YBOJYGJMKPMNRC-QRIWDNSUSA-N |
Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Kinoshita et al (2001) Novel wasp toxin discriminates between neuronal and cardiac sodium channels. Mol.Pharmacol. 59 1457 PMID: 11353806
Konno et al (1998) Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms. Biochem.Biophys.Res.Commun. 250 612 PMID: 9784394
Miyawaki et al (2002) Differential effects of novel wasp toxin on rat hippocampal interneurons. Neurosci.Lett. 328 25 PMID: 12123851
Keywords: beta-Pompilidotoxin, beta-Pompilidotoxin supplier, Slows, neuronal, Na+, channels, inactivation, Sodium, NaV, voltage-gated, voltage-dependent, beta-Pompilidotoxin, β-PMTX, beta-PMTX, neurotoxins, venoms, b-PMTX, Voltage-gated, Channels, 1539, Tocris Bioscience
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