Novel wasp neurotoxin that slows Na+ channel inactivation. Facilitates neuromuscular synaptic transmission and discriminates between rat neuronal and cardiac Na+ channel α-subunits.
Sold with the permission of Suntory Ltd.
(Modifications: Leu-13 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1557.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.64 mL||3.21 mL||6.42 mL|
|5 mM||0.13 mL||0.64 mL||1.28 mL|
|10 mM||0.06 mL||0.32 mL||0.64 mL|
|50 mM||0.01 mL||0.06 mL||0.13 mL|
References are publications that support the biological activity of the product.
Kinoshita et al (2001) Novel wasp toxin discriminates between neuronal and cardiac sodium channels. Mol.Pharmacol. 59 1457 PMID: 11353806
Konno et al (1998) Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms. Biochem.Biophys.Res.Commun. 250 612 PMID: 9784394
Miyawaki et al (2002) Differential effects of novel wasp toxin on rat hippocampal interneurons. Neurosci.Lett. 328 25 PMID: 12123851
If you know of a relevant reference for β-Pompilidotoxin, please let us know.
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Keywords: beta-Pompilidotoxin, beta-Pompilidotoxin supplier, Slows, neuronal, Na+, channels, inactivation, Sodium, NaV, voltage-gated, voltage-dependent, beta-Pompilidotoxin, β-PMTX, beta-PMTX, neurotoxins, venoms, b-PMTX, Voltage-gated, Channels, 1539, Tocris Bioscience
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