You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for β-Lapachone
β-Lapachone is a DNA topoisomerase I inhibitor. Exhibits a different inhibitory mechanism to camptothecin (Cat. No. 1100). Induces apoptosis in a variety of cell lines, including prostate cancer and promyelocytic leukemia cells; blocks the cell cycle in G0/G1. Also has effects on DNA topoisomerase II, NF-κB, AP-1, and JNK.
Compound Libraries for β-Lapachone
Technical Data for β-Lapachone
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for β-Lapachone
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for β-Lapachone
The following data is based on the product molecular weight 242.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.13 mL||20.64 mL||41.28 mL|
|5 mM||0.83 mL||4.13 mL||8.26 mL|
|10 mM||0.41 mL||2.06 mL||4.13 mL|
|50 mM||0.08 mL||0.41 mL||0.83 mL|
References for β-Lapachone
References are publications that support the biological activity of the product.
Li et al (1993) Beta-Lapachone, a novel topoisomerase I inhibitor with a mode of action different from camptothecin. J.Biol.Chem. 268 22463 PMID: 8226754
Manna et al (1999) Suppression of tumor necrosis factor-activated nuclear transcription factor-κB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by β lapachone. Biochem.Pharmacol. 57 763 PMID: 10075082
Shiah et al (1999) Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor β-lapachone-induced apoptosis through an oxidation-dependent pathway Cancer Res. 59 391 PMID: 9927052
Wuerzberger et al (1998) Induction of apoptosis in MCF-7:WS8 breast cancer cells by β-Lapachone. Cancer Res. 58 1876 PMID: 9581828
If you know of a relevant reference for β-Lapachone, please let us know.
View Related Products by Product Action
Keywords: beta-Lapachone, beta-Lapachone supplier, DNA, topoisomerase, I, inhibitors, inhibits, apoptosis, proapoptotic, b-lapachone, beta-lapachone, β-lapachone, Topoisomerase, 1293, Tocris Bioscience
1 Citation for β-Lapachone
Citations are publications that use Tocris products. Selected citations for β-Lapachone include:
Joshi et al (2016) Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1. Cell Death Differ 23 216 PMID: 26138443
Do you know of a great paper that uses β-Lapachone from Tocris? Please let us know.
Reviews for β-Lapachone
There are currently no reviews for this product. Be the first to review β-Lapachone and earn rewards!
Have you used β-Lapachone?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.