Selective μ opioid receptor antagonist.
Sold with the permission of the University of Minnesota
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||20mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 490.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.04 mL||10.18 mL||20.37 mL|
|5 mM||0.41 mL||2.04 mL||4.07 mL|
|10 mM||0.2 mL||1.02 mL||2.04 mL|
|50 mM||0.04 mL||0.2 mL||0.41 mL|
References are publications that support the products' biological activity.
Jiang et al (1990) μ Antagonist and κ agonist properties of β-funaltrexamine (β-FNA) in vivo: long lasting spinal analgesia in mice. J.Pharmacol.Exp.Ther. 252 1006 PMID: 2156986
Takemorei et al (1981) The irreversible narcotic antagonist and reversible agonist properties of the fumarate methyl ester derivative of naltrexone. Eur.J.Pharmacol. 70 445 PMID: 6263637
If you know of a relevant reference for β-Funaltrexamine hydrochloride, please let us know.
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Keywords: beta-Funaltrexamine hydrochloride, supplier, Irreversible, μ-opioid, mu-opioid, selective, antagonists, MOP, Receptors, OP3, β-Funaltrexamine, beta-Funaltrexamine, hydrochloride, β-FNA, beta-FNA, b-FNA, Mu, Opioid, Receptors, Mu, Opioid, Receptors, Tocris Bioscience
5 Citations for β-Funaltrexamine hydrochloride
Citations are publications that use Tocris products. Selected citations for β-Funaltrexamine hydrochloride include:
Romero-Picó et al (2013) Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin. Circulation 38 1296 PMID: 23348063
Tzeng et al (2011) Myricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats. Evid Based Complement Alternat Med 2011 150752 PMID: 21785619
Largent-Milnes et al (2010) Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. Br J Pharmacol 161 986 PMID: 20977451
Cecchi et al (2008) Differential responses to morphine-induced analgesia in the tail-flick test. Behav Brain Res 194 146 PMID: 18656501
Chen et al (2015) Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. Neuropsychopharmacology 10 e0145556 PMID: 26700862
Do you know of a great paper that uses β-Funaltrexamine hydrochloride from Tocris? If so please let us know.
beta-Funaltrexamine hydrochloride Reviews
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