β-Funaltrexamine hydrochloride

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Cat.No. 0926 - beta-Funaltrexamine hydrochloride | C25H30N2O6.HCl | CAS No. 72786-10-8
Description: Irreversible μ-selective antagonist
Alternative Names: β-FNA
Chemical Name: (E)-4-[[5α,6β)-17-Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]amino]-4-oxo-2-butenoicacid methyl ester hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Literature

Biological Activity

Selective μ opioid receptor antagonist.

Licensing Information

Sold with the permission of the University of Minnesota

Compound Libraries

β-Funaltrexamine hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 490.99
Formula C25H30N2O6.HCl
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 72786-10-8
PubChem ID 44522395
InChI Key BIPHUOBUKMPSQR-NQGXHZAGSA-N
Smiles OC1=C(O4)C([C@]([C@@H]4[C@@](NC(/C=C/C(OC)=O)=O)([H])CC3)5[C@]3(O)[C@H](N(CC6CC6)CC5)C2)=C2C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.1 100
water 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 490.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.18 mL 20.37 mL
5 mM 0.41 mL 2.04 mL 4.07 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Jiang et al (1990) μ Antagonist and κ agonist properties of β-funaltrexamine (β-FNA) in vivo: long lasting spinal analgesia in mice. J.Pharmacol.Exp.Ther. 252 1006 PMID: 2156986

Takemorei et al (1981) The irreversible narcotic antagonist and reversible agonist properties of the fumarate methyl ester derivative of naltrexone. Eur.J.Pharmacol. 70 445 PMID: 6263637


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5 Citations for β-Funaltrexamine hydrochloride

Citations are publications that use Tocris products. Selected citations for β-Funaltrexamine hydrochloride include:

Romero-Picó et al (2013) Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin. Circulation 38 1296 PMID: 23348063

Tzeng et al (2011) Myricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats. Evid Based Complement Alternat Med 2011 150752 PMID: 21785619

Largent-Milnes et al (2010) Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. Br J Pharmacol 161 986 PMID: 20977451

Cecchi et al (2008) Differential responses to morphine-induced analgesia in the tail-flick test. Behav Brain Res 194 146 PMID: 18656501

Chen et al (2015) Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. Neuropsychopharmacology 10 e0145556 PMID: 26700862


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