β-Funaltrexamine hydrochloride

Discontinued Product

β-Funaltrexamine hydrochloride (Cat. No. 0926) has been withdrawn from sale for commercial reasons.
Description: Irreversible and selective μ antagonist
Alternative Names: β-FNA
Chemical Name: (E)-4-[[5α,6β)-17-Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]amino]-4-oxo-2-butenoicacid methyl ester hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews
Literature (2)

Biological Activity for β-Funaltrexamine hydrochloride

β-Funaltrexamine hydrochloride is a selective μ opioid receptor antagonist.

Licensing Information

Sold with the permission of the University of Minnesota

Technical Data for β-Funaltrexamine hydrochloride

M. Wt 490.99
Formula C25H30N2O6.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 72786-10-8
PubChem ID 44522395
InChI Key BIPHUOBUKMPSQR-NQGXHZAGSA-N
Smiles Cl.[H][C@@]12OC3=C4C(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC[C@H]2NC(=O)\C=C\C(=O)OC)=CC=C3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for β-Funaltrexamine hydrochloride

Certificate of Analysis / Product Datasheet
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References for β-Funaltrexamine hydrochloride

References are publications that support the biological activity of the product.

Jiang et al (1990) μ Antagonist and κ agonist properties of β-funaltrexamine (β-FNA) in vivo: long lasting spinal analgesia in mice. J.Pharmacol.Exp.Ther. 252 1006 PMID: 2156986

Takemorei et al (1981) The irreversible narcotic antagonist and reversible agonist properties of the fumarate methyl ester derivative of naltr. Eur.J.Pharmacol. 70 445 PMID: 6263637

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7 Citations for β-Funaltrexamine hydrochloride

Citations are publications that use Tocris products. Selected citations for β-Funaltrexamine hydrochloride include:

Romero-Picó et al (2013) Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin. Circulation 38 1296 PMID: 23348063

Tzeng et al (2011) Myricetin Ameliorates Defective Post-Receptor Ins Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats. Evid Based Complement Alternat Med 2011 150752 PMID: 21785619

Crowley et al (2020) Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ Opioid Receptor. ACS Chem Neurosci 11 1781 PMID: 32383854

Phillips et al (2012) Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression. J Neurophysiol 108 2393 PMID: 22956800


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.