Endogenous estrogen receptor (ER) agonist (Ki values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 272.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.67 mL||18.36 mL||36.71 mL|
|5 mM||0.73 mL||3.67 mL||7.34 mL|
|10 mM||0.37 mL||1.84 mL||3.67 mL|
|50 mM||0.07 mL||0.37 mL||0.73 mL|
References are publications that support the products' biological activity.
Kuiper et al (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138 863 PMID: 9048584
Thomas et al (2005) Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146 624 PMID: 15539556
If you know of a relevant reference for β-Estradiol, please let us know.
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2 Citations for β-Estradiol
Citations are publications that use Tocris products. Selected citations for β-Estradiol include:
Al-Khyatt (2018) Selective oestrogen receptor antagonists inhibit oesophageal cancer cell proliferation in vitro. BMC Cancer 18 121 PMID: 29390981
Leal et al (2012) p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF. PLoS One 7 e49817 PMID: 23239970
Do you know of a great paper that uses β-Estradiol from Tocris? If so please let us know.
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Literature in this Area
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