β-Estradiol

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Cat.No. 2824 - beta-Estradiol | C18H24O2 | CAS No. 50-28-2
Description: Endogenous ER agonist
Alternative Names: 17 β-Estradiol
Chemical Name: (17β)-Estra-1,3,5(10)-triene-3,17-diol
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature
Pathways

Biological Activity

Endogenous estrogen receptor (ER) agonist (Ki values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.

α-Estradiol and Deuterated analog also available.

Technical Data

M. Wt 272.38
Formula C18H24O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 50-28-2
PubChem ID 5757
InChI Key VOXZDWNPVJITMN-ZBRFXRBCSA-N
Smiles [H][C@@]23CCC1=CC(O)=CC=C1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.24 100
ethanol 20.43 75

Preparing Stock Solutions

The following data is based on the product molecular weight 272.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.67 mL 18.36 mL 36.71 mL
5 mM 0.73 mL 3.67 mL 7.34 mL
10 mM 0.37 mL 1.84 mL 3.67 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Kuiper et al (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138 863 PMID: 9048584

Thomas et al (2005) Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146 624 PMID: 15539556


If you know of a relevant reference for β-Estradiol, please let us know.

View Related Products by Product Action

View all Estrogen and Related Receptor Agonists

Keywords: beta-Estradiol, beta-Estradiol supplier, Endogenous, ER, agonists, Estrogen, Receptors, GPR30, beta-Estradiol, b-estradiol, β-estradiol, 17, β-Estradiol, beta-estradiol, GPER, 17b-Estradiol, and, Related, (GPER), 2824, Tocris Bioscience

3 Citations for β-Estradiol

Citations are publications that use Tocris products. Selected citations for β-Estradiol include:

Al-Khyatt (2018) Selective oestrogen receptor antagonists inhibit oesophageal cancer cell proliferation in vitro. BMC Cancer 18 121 PMID: 29390981

Hood et al (2016) Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16α-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension. Hypertension 68 796 PMID: 27402919

Leal et al (2012) p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF. PLoS One 7 e49817 PMID: 23239970


Do you know of a great paper that uses β-Estradiol from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
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  • Retinoid X Receptors
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Pathways for β-Estradiol

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.