α-Estradiol

Pricing Availability Delivery Time Qty
Cat.No. 2823 - alpha-Estradiol | C18H24O2 | CAS No. 57-91-0
Description: Endogenous estrogen receptor agonist
Chemical Name: (17α)-Estra-1,3,5(10)-triene-3,17-diol
Purity: ≥96% (HPLC)
Datasheet
Citations (3)
Literature
Pathways

Biological Activity

Endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively). β-Estradiol (Cat. No. 2824) also available.

Technical Data

M. Wt 272.38
Formula C18H24O2
Storage Store at RT
Purity ≥96% (HPLC)
CAS Number 57-91-0
PubChem ID 68570
InChI Key VOXZDWNPVJITMN-SFFUCWETSA-N
Smiles [H][C@@]23CCC1=CC(O)=CC=C1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@H]4O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.24 100
ethanol 27.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 272.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.67 mL 18.36 mL 36.71 mL
5 mM 0.73 mL 3.67 mL 7.34 mL
10 mM 0.37 mL 1.84 mL 3.67 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kuiper et al (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138 863 PMID: 9048584

Toran-Allerand et al (2002) ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. J.Neurosci. 22 8391 PMID: 12351713


If you know of a relevant reference for α-Estradiol, please let us know.

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3 Citations for α-Estradiol

Citations are publications that use Tocris products. Selected citations for α-Estradiol include:

Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192 PMID: 26074768

Dexter et al (2015) Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae. Sci Rep 9 17 PMID: 25888817

McIsaac et al (2012) Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway. Mol Biol Cell 23 2993 PMID: 22696683


Do you know of a great paper that uses α-Estradiol from Tocris? If so please let us know.

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Reviews

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Literature in this Area

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Nuclear Receptors Product Listing

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Pathways for α-Estradiol

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.

Protocols

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