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Biological Activity for α-Estradiol
α-Estradiol is an endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).
β-Estradiol also available.
Technical Data for α-Estradiol
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for α-Estradiol
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for α-Estradiol
The following data is based on the product molecular weight 272.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.67 mL||18.36 mL||36.71 mL|
|5 mM||0.73 mL||3.67 mL||7.34 mL|
|10 mM||0.37 mL||1.84 mL||3.67 mL|
|50 mM||0.07 mL||0.37 mL||0.73 mL|
References for α-Estradiol
References are publications that support the biological activity of the product.
Kuiper et al (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138 863 PMID: 9048584
Toran-Allerand et al (2002) ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. J.Neurosci. 22 8391 PMID: 12351713
If you know of a relevant reference for α-Estradiol, please let us know.
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3 Citations for α-Estradiol
Citations are publications that use Tocris products. Selected citations for α-Estradiol include:
McIsaac et al (2012) Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway. Mol Biol Cell 23 2993 PMID: 22696683
Tozzi et al (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci 9 192 PMID: 26074768
Dexter et al (2015) Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae. Sci Rep 9 17 PMID: 25888817
Do you know of a great paper that uses α-Estradiol from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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