Discontinued Product

Azilsartan (Cat. No. 4553) has been withdrawn from sale for commercial reasons.
Description: Potent AT1 inverse agonist; antihypertensive
Chemical Name: 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
Purity: ≥98% (HPLC)

Biological Activity for Azilsartan

Azilsartan is a potent angiotensin II type 1 (AT1) receptor inverse agonist (IC50 = 2.6 nM at the human AT1 receptor). Inhibits angiotensin II-induced IP1 accumulation in COS-7 cells; decreases maximal contraction of rabbit aortic strips in a concentration-dependent manner (pD'2 = 9.9). Antihypertensive; prevents vascular cell proliferation and expression of PAI-1.

Compound Libraries for Azilsartan

Azilsartan is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Azilsartan

M. Wt 456.45
Formula C25H20N4O5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 147403-03-0
PubChem ID 9825285
Smiles O=C1NC(C2=CC=CC=C2C(C=C5)=CC=C5CN4C3=C(C(O)=O)C=CC=C3N=C4OCC)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Azilsartan

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