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Azido-Thalidomide

Cat. No. 6300 Submit a Review Datasheet / COA / SDS
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Cat.No. 6300 - Azido-Thalidomide | C19H20N6O6 | CAS No. 2098488-36-7
Description: Azide-functionalized Thalidomide, 'click' ligand for PROTACs
Chemical Name: N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Click-activated Thalidomide (Cat.No. 0652) that can be used as a precursor to PROTACs that hijack cereblon as the E3 ubiquitin ligase component. Supplied with an azide functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.

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Technical Data

M. Wt 428.4
Formula C19H20N6O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2098488-36-7
Smiles [N-]=[N+]=NCCCCNC(COC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 428.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Schiedel et al (2018) Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals). J.Med.Chem. 61 482 PMID: 28379698

If you know of a relevant reference for Azido-Thalidomide, please let us know.

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Citations for Azido-Thalidomide

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