Azido-ThalidomideNew
Biological Activity
Click-activated Thalidomide (Cat.No. 0652) that can be used as a precursor to PROTACs that hijack cereblon as the E3 ubiquitin ligase component. Supplied with an azide functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.
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Technical Data
| M. Wt | 428.4 |
| Formula | C19H20N6O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2098488-36-7 |
| Smiles | [N-]=[N+]=NCCCCNC(COC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.84 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 428.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.67 mL | 23.34 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Schiedel et al (2018) Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals). J.Med.Chem. 61 482 PMID: 28379698
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Keywords: Azido-Thalidomide, supplier, PROTACs, click-activated, thalidomide, E3, ligase, ligands, cereblon, Tools, for, PROTAC, R&D, Tools, for, PROTAC, R&D, Tocris Bioscience
Citations for Azido-Thalidomide
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