Azido-ThalidomideNew
Biological Activity
Click-activated Thalidomide (Cat.No. 0652) that can be used as a precursor to PROTACs that hijack cereblon as the E3 ubiquitin ligase component. Supplied with an azide functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.
Require a different derivative? Get in touch.
Technical Data
| M. Wt | 428.4 |
| Formula | C19H20N6O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2098488-36-7 |
| Smiles | [N-]=[N+]=NCCCCNC(COC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.84 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 428.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.67 mL | 23.34 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the biological activity of the product.
Schiedel et al (2018) Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals). J.Med.Chem. 61 482 PMID: 28379698
If you know of a relevant reference for Azido-Thalidomide, please let us know.
View Related Products by Target
Keywords: Azido-Thalidomide, Azido-Thalidomide supplier, PROTACs, click-activated, thalidomide, E3, ligase, ligands, cereblon, Tools, for, PROTAC, R&D, 6300, Tocris Bioscience
Citations for Azido-Thalidomide
Citations are publications that use Tocris products.
Currently there are no citations for Azido-Thalidomide. Do you know of a great paper that uses Azido-Thalidomide from Tocris? Please let us know.
Reviews for Azido-Thalidomide
There are currently no reviews for this product. Be the first to review Azido-Thalidomide and earn rewards!
Have you used Azido-Thalidomide?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Spring/Summer 2018)New
Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
- 7-TM Receptors
- Enzymes
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Transporters
- Aptamers
- Cell Metabolism
- Epigenetics
- Fluorescent Imaging
- Signal Transduction
- Stem Cells
