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AZ 6102 is a potent TNKS2 and TNKS1 inhibitor (IC50 values are 1 and 3 nM, respectively). Exhibits >100-fold selectivity for TNKS1/2 over PARP-1, PARP-2 and PARP-6. Inhibits Wnt signaling in DLD-1 cells (IC50 = 5 nM). Exhibits moderate oral bioavailability.
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of AZ6102 is reviewed on the chemical probes website.
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|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 428.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.67 mL||23.34 mL||46.67 mL|
|2.5 mM||0.93 mL||4.67 mL||9.33 mL|
|5 mM||0.47 mL||2.33 mL||4.67 mL|
|25 mM||0.09 mL||0.47 mL||0.93 mL|
References are publications that support the biological activity of the product.
Johannes et al (2015) Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. ACS Med.Chem.Lett. 13 254 PMID: 25815142
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Keywords: AZ 6102, AZ 6102 supplier, AZ6102, potent, selective, TNKS1, TNKS2, inhibitors, inhibits, tankyrases, Wnt, signaling, Tankyrase, 5775, Tocris Bioscience
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