AZ 10417808

Pricing Availability   Qty
Cat.No. 2172 - AZ 10417808 | C18H13Cl2N5O4 | CAS No. 331645-84-2
Description: Selective non-peptide caspase-3 inhibitor
Alternative Names: AQZ-1
Chemical Name: 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 μM). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC50 = 14.9 μM).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

AZ 10417808 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 434.23
Formula C18H13Cl2N5O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 331645-84-2
PubChem ID 16759160
InChI Key VUBILPOZTRGZJK-UHFFFAOYSA-N
Smiles [O-][N+](=O)C1=CC2=C(N=C(NC3=CC(Cl)=C(Cl)C=C3)NC2=O)C(=C1)C(=O)NCC=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.86 25

Preparing Stock Solutions

The following data is based on the product molecular weight 434.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.21 mL 46.06 mL 92.12 mL
1.25 mM 1.84 mL 9.21 mL 18.42 mL
2.5 mM 0.92 mL 4.61 mL 9.21 mL
12.5 mM 0.18 mL 0.92 mL 1.84 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Scott et al (2003) Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis. J.Pharmacol.Exp.Ther. 304 433 PMID: 12490620


If you know of a relevant reference for AZ 10417808, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Caspase Inhibitors

Keywords: AZ 10417808, AZ 10417808 supplier, Selective, non-peptide, caspase-3, inhibitors, inhibits, Caspases, Proteinases, Proteases, AZ10417808, AstraZeneca, AQZ-1, 2172, Tocris Bioscience

1 Citation for AZ 10417808

Citations are publications that use Tocris products. Selected citations for AZ 10417808 include:

Cruz et al (2013) High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses. PLoS Negl Trop Dis 7 e2073 PMID: 23437413


Do you know of a great paper that uses AZ 10417808 from Tocris? Please let us know.

Reviews for AZ 10417808

There are currently no reviews for this product. Be the first to review AZ 10417808 and earn rewards!

Have you used AZ 10417808?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Huntington's Disease

Huntington's Disease Poster

Huntington's disease (HD) is a monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the MSN intracellular signaling pathways implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.