AZ 10417808

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Cat.No. 2172 - AZ 10417808 | C18H13Cl2N5O4 | CAS No. 331645-84-2
Description: Selective non-peptide caspase-3 inhibitor
Alternative Names: AQZ-1
Chemical Name: 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 μM). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC50 = 14.9 μM).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

AZ 10417808 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 434.23
Formula C18H13Cl2N5O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 331645-84-2
PubChem ID 16759160
InChI Key VUBILPOZTRGZJK-UHFFFAOYSA-N
Smiles [O-][N+](=O)C1=CC2=C(N=C(NC3=CC(Cl)=C(Cl)C=C3)NC2=O)C(=C1)C(=O)NCC=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.86 25

Preparing Stock Solutions

The following data is based on the product molecular weight 434.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.51 mL 23.03 mL
5 mM 0.46 mL 2.3 mL 4.61 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Scott et al (2003) Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis. J.Pharmacol.Exp.Ther. 304 433 PMID: 12490620


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Keywords: AZ 10417808, supplier, Selective, non-peptide, caspase-3, inhibitors, inhibits, Caspases, Proteinases, Proteases, AZ10417808, AstraZeneca, AQZ-1, Caspases, Tocris Bioscience

1 Citation for AZ 10417808

Citations are publications that use Tocris products. Selected citations for AZ 10417808 include:

Cruz et al (2013) High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses. PLoS Negl Trop Dis 7 e2073 PMID: 23437413


Do you know of a great paper that uses AZ 10417808 from Tocris? If so please let us know.

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Literature in this Area

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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

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Huntington's Disease Poster

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Pathways for AZ 10417808

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