ATC 0175 hydrochloride

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Cat.No. 3346 - ATC 0175 hydrochloride | C23H25F2N5O.HCl | CAS No. 510733-97-8
Description: MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist
Chemical Name: N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamide hydrochloride
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for ATC 0175 hydrochloride

ATC 0175 hydrochloride is a potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT2B and 5-HT1A receptors (IC50 values are 9.66 and 16.9 nM respectively).

Technical Data for ATC 0175 hydrochloride

M. Wt 461.94
Formula C23H25F2N5O.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 510733-97-8
PubChem ID 9934032
Smiles O=C(C4=CC(F)=C(F)C=C4)N[C@@H](CC3)CC[C@@H]3NC2=NC1=CC=CC=C1C(N(C)C)=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ATC 0175 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.62 10
ethanol 11.55 25

Preparing Stock Solutions for ATC 0175 hydrochloride

The following data is based on the product molecular weight 461.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 8.66 mL 43.3 mL 86.59 mL
1.25 mM 1.73 mL 8.66 mL 17.32 mL
2.5 mM 0.87 mL 4.33 mL 8.66 mL
12.5 mM 0.17 mL 0.87 mL 1.73 mL

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Product Datasheets for ATC 0175 hydrochloride

Certificate of Analysis / Product Datasheet
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References for ATC 0175 hydrochloride

References are publications that support the biological activity of the product.

Chaki et al (2005) Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J.Pharmacol.Exp.Ther. 313 831 PMID: 15677346

Chaki et al (2005) ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 11 341 PMID: 16614734

If you know of a relevant reference for ATC 0175 hydrochloride, please let us know.

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Citations for ATC 0175 hydrochloride

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