ATC 0175 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3346 - ATC 0175 hydrochloride | C23H25F2N5O.HCl | CAS No. 510733-97-8
Description: MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist
Chemical Name: N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT2B and 5-HT1A receptors (IC50 values are 9.66 and 16.9 nM respectively).

Technical Data

M. Wt 461.94
Formula C23H25F2N5O.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 510733-97-8
PubChem ID 9934032
InChI Key HUUPKFUYSQNNLO-UHFFFAOYSA-N
Smiles O=C(C4=CC(F)=C(F)C=C4)N[C@@H](CC3)CC[C@@H]3NC2=NC1=CC=CC=C1C(N(C)C)=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.62 10
ethanol 11.55 25

Preparing Stock Solutions

The following data is based on the product molecular weight 461.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.82 mL 21.65 mL
5 mM 0.43 mL 2.16 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chaki et al (2005) Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J.Pharmacol.Exp.Ther. 313 831 PMID: 15677346

Chaki et al (2005) ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 11 341 PMID: 16614734


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Citations for ATC 0175 hydrochloride

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