ASP 9521

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Cat.No. 6084 - ASP 9521 | C19H26N2O3 | CAS No. 1126084-37-4
Description: Potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor;orally bioavailable
Chemical Name: [4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone
Purity: ≥98% (HPLC)

Biological Activity for ASP 9521

ASP 9521 is a potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor (IC50 = 11 - 49 nM). Suppresses androstenedione-dependent protein-specific antigen (PSA) production and cell proliferation in LNCaP cells in vitro. Orally bioavailable.

Technical Data for ASP 9521

M. Wt 330.42
Formula C19H26N2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1126084-37-4
PubChem ID 25210792
Smiles O=C(N1CCC(CC1)CC(C)(O)C)C2=CC3=CC(OC)=CC=C3N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ASP 9521

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.04 100
ethanol 33.04 100

Preparing Stock Solutions for ASP 9521

The following data is based on the product molecular weight 330.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.13 mL 30.26 mL
5 mM 0.61 mL 3.03 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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References for ASP 9521

References are publications that support the biological activity of the product.

Kikuchi et al (2014) In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). Invest.New Drugs 32 860 PMID: 24981575

If you know of a relevant reference for ASP 9521, please let us know.

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Citations for ASP 9521

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