ASP 9521

Discontinued Product

ASP 9521 (Cat. No. 6084) has been withdrawn from sale for commercial reasons.
Description: Potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor;orally bioavailable
Chemical Name: [4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for ASP 9521

ASP 9521 is a potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor (IC50 = 11 - 49 nM). Suppresses androstenedione-dependent protein-specific antigen (PSA) production and cell proliferation in LNCaP cells in vitro. Orally bioavailable.

Technical Data for ASP 9521

M. Wt 330.42
Formula C19H26N2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1126084-37-4
PubChem ID 25210792
Smiles O=C(N1CCC(CC1)CC(C)(O)C)C2=CC3=CC(OC)=CC=C3N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ASP 9521

References are publications that support the biological activity of the product.

Kikuchi et al (2014) In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). Invest.New Drugs 32 860 PMID: 24981575

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Keywords: ASP 9521, ASP 9521 supplier, ASP9521, 17beta, 17B, hydroxysteroid, dehydrogenase, type, 5, inhibitors, inhibits, 17β-HSD5, AK1RC3, potent, orally, bioavailable, Other, Dehydrogenases, 6084, Tocris Bioscience

Citations for ASP 9521

Citations are publications that use Tocris products.

Currently there are no citations for ASP 9521.

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Literature in this Area

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