ASP 2535

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Cat.No. 5308 - ASP 2535 | C22H18N6O | CAS No. 374886-51-8
Description: Potent and selective GlyT1 inhibitor
Chemical Name: 4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective GlyT1 inhibitor (IC50 = 92 nM). Exhibits 50-fold selectivity over GlyT2. Attenuates MK 801-induced working memory deficits and PCP-induced visual learning deficits in mice. Orally available and brain penetrant.

Compound Libraries

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Technical Data

M. Wt 382.42
Formula C22H18N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 374886-51-8
PubChem ID 9800113
InChI Key FQGLDGKVKDPVLO-UHFFFAOYSA-N
Smiles CC(C)C1=NN=C(C4=CN=C(C5=CC=CC=C5)C=C4)N1C3=CC=CC2=NON=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.24 100
ethanol 38.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 382.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.07 mL 26.15 mL
5 mM 0.52 mL 2.61 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Harada et al (2012) A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's diseas Eur.J.Pharmacol. 685 59 PMID: 22542656


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Keywords: ASP2535 potent selective glycine transporters GlyT1 inhibitors inhibits schizophrenia alzheimer's disease Glycine Transporters

Citations for ASP 2535

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Literature in this Area

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster highlights the targets and pathways representing the most promising strategies to pursue for novel drug development.

Pathways for ASP 2535

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