Phencyclidine hydrochloride

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Cat.No. 2557 - Phencyclidine hydrochloride | C17H25N.HCl | CAS No. 956-90-1
Description: Non-competitive NMDA receptor antagonist
Alternative Names: PCP
Chemical Name: 1-(1-Phenylcyclohexyl)piperidine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Non-competitive NMDA receptor antagonist and sigma receptor agonist. Psychostimulant; induces rotational behavior, head-weaving and cognitive dysfunction in rats.

Technical Data

M. Wt 279.85
Formula C17H25N.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 956-90-1
PubChem ID 13727
InChI Key BUAJNGPDPGKBGV-UHFFFAOYSA-N
Smiles N2(CCCCC2)C1(C3=CC=CC=C3)CCCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.19 40

Preparing Stock Solutions

The following data is based on the product molecular weight 279.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.57 mL 17.87 mL 35.73 mL
5 mM 0.71 mL 3.57 mL 7.15 mL
10 mM 0.36 mL 1.79 mL 3.57 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Linders et al (1993) Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrochloride: a new potent and selective electrophilic affinity ligand for the NMDA receptor-c J.Med.Chem. 36 2499 PMID: 8355251

Jin et al (1997) The involvement of σ receptors in the choice reaction performance deficits induced by phencyclidine. Eur.J.Pharmacol. 319 147 PMID: 9042584

Sharp (1997) Phencyclidine (PCP) acts at σ sites to induce c-fos gene expression. Brain Res. 758 51 PMID: 9203533


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Keywords: Phencyclidine hydrochloride, supplier, σ, sigma, receptor, agonists, Non-competitive, NMDA, antagonists, General, Receptors, Glutamate, N-Methyl-D-Aspartate, iGluR, Ionotropic, PCP, NMDA, Receptors, Sigma-Related, NMDA, Receptors, Tocris Bioscience

Citations for Phencyclidine hydrochloride

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