Phencyclidine hydrochloride

Pricing Availability   Qty
Description: Non-competitive NMDA antagonist
Alternative Names: PCP
Chemical Name: 1-(1-Phenylcyclohexyl)piperidine hydrochloride
Purity: ≥99% (HPLC)
Literature (5)

Biological Activity for Phencyclidine hydrochloride

Phencyclidine hydrochloride is a non-competitive NMDA receptor antagonist and sigma receptor agonist. Psychostimulant; induces rotational behavior, head-weaving and cognitive dysfunction in rats.

Technical Data for Phencyclidine hydrochloride

M. Wt 279.85
Formula C17H25N.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 956-90-1
PubChem ID 13727
Smiles N2(CCCCC2)C1(C3=CC=CC=C3)CCCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Phencyclidine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 11.19 40

Preparing Stock Solutions for Phencyclidine hydrochloride

The following data is based on the product molecular weight 279.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.4 mM 8.93 mL 44.67 mL 89.33 mL
2 mM 1.79 mL 8.93 mL 17.87 mL
4 mM 0.89 mL 4.47 mL 8.93 mL
20 mM 0.18 mL 0.89 mL 1.79 mL

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Product Datasheets for Phencyclidine hydrochloride

Certificate of Analysis / Product Datasheet
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References for Phencyclidine hydrochloride

References are publications that support the biological activity of the product.

Linders et al (1993) Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrochloride: a new potent and selective electrophilic affinity ligand for the NMDA receptor-c J.Med.Chem. 36 2499 PMID: 8355251

Jin et al (1997) The involvement of σ receptors in the choice reaction performance deficits induced by phencyclidine. Eur.J.Pharmacol. 319 147 PMID: 9042584

Sharp (1997) Phencyclidine (PCP) acts at σ sites to induce c-fos gene expression. Brain Res. 758 51 PMID: 9203533

If you know of a relevant reference for Phencyclidine hydrochloride, please let us know.

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Keywords: Phencyclidine hydrochloride, Phencyclidine hydrochloride supplier, σ, sigma, receptor, agonists, Non-competitive, NMDA, antagonists, General, Receptors, Glutamate, N-Methyl-D-Aspartate, iGluR, Ionotropic, PCP, Sigma-Related, 2557, Tocris Bioscience

Citations for Phencyclidine hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Phencyclidine hydrochloride. Do you know of a great paper that uses Phencyclidine hydrochloride from Tocris? Please let us know.

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Literature in this Area

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