Ascomycin
Biological Activity
Analog of FK 506 (Cat. No. 3631); binds to FK 506-binding protein 12 (FKBP12) in order to inhibit calcineurin phosphatase activity (IC50 = 49 nM) and activation of nuclear factor of activated T cells (NFAT). Displays antifungal and immunosuppressive activities.
Technical Data
| M. Wt | 792.01 |
| Formula | C43H69NO12 |
| Storage | Store at -20°C |
| CAS Number | 104987-12-4 |
| PubChem ID | 5282071 |
| InChI Key | ZDQSOHOQTUFQEM-NURRSENYSA-N |
| Smiles | O[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](O4)[C@H](C)[C@@H](O)CC([C@H](CC)/C=C(C)/C[C@H](C)C[C@H](OC)[C@@]2([H])O[C@](C(C(N3[C@@](C4=O)([H])CCCC3)=O)=O)(O)[C@H](C)C[C@@H]2OC)=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.6 | 50 | |
| ethanol | 39.6 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 792.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.26 mL | 6.31 mL | 12.63 mL |
| 5 mM | 0.25 mL | 1.26 mL | 2.53 mL |
| 10 mM | 0.13 mL | 0.63 mL | 1.26 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.25 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Motamedi et al (1996) Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520. J.Bacteriol. 178 5243 PMID: 8752344
Arndt et al (1999) Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans. Microbiology 145 1989 PMID: 10463165
Revill et al (2002) Genetically engineered analogs of ascomycin for nerve regeneration. J.Pharmacol.Exp.Ther. 302 1278 PMID: 12183690
Hatanaka et al (1988) FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physicochemical and biological characteristics. J.Antibiot (Tokyo). 41 1593 PMID:
If you know of a relevant reference for Ascomycin, please let us know.
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Keywords: Ascomycin, supplier, FK520, FR900520, Ascomycin, calcineurin, phosphatase, inhibitors, inhibits, analogs, FK, 506, fkbp12, immunosuppressives, antifungals, antibiotics, FK, 520, FR, 900520, Protein, Ser/Thr, Phosphatases, Tocris Bioscience
Citations for Ascomycin
Citations are publications that use Tocris products.
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