AS 252424

Pricing Availability Delivery Time Qty
Cat.No. 3671 - AS 252424 | C14H8FNO4S | CAS No. 900515-16-4
Description: Selective inhibitor of PI 3-kinase γ
Chemical Name: 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent and selective inhibitor of PI 3-kinase γ (IC50 values are 33 and 935 nM for PI 3-Kγ and PI 3-Kα respectively).

Technical Data

M. Wt 305.28
Formula C14H8FNO4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 900515-16-4
PubChem ID 11630874
InChI Key OYYVWNDMOQPMGE-SDQBBNPISA-N
Smiles OC1=CC(F)=CC=C1C2=CC=C(\C=C3/SC(NC3=O)=O)O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.53 100
ethanol 1.53 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 305.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.38 mL 32.76 mL
5 mM 0.66 mL 3.28 mL 6.55 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Condliffe et al (2005) Sequential activation of class IB and IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106 1432 PMID: 15878979

Pomel et al (2006) Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. J.Med.Chem. 49 3857 PMID: 16789742


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Keywords: AS 252424, supplier, PI3Kgamma, PI3Kγ, PI, 3-kinasegamma, 3-kinaseg, 3-kinaseγ, phosphoinositide, 3, kinases, gamma, γ, signalling, signaling, inositol, lipids, selective, inhibitors, inhibits, AS252424, pi3k, PI, 3-Kinase, PI, 3-Kinase, Tocris Bioscience

1 Citation for AS 252424

Citations are publications that use Tocris products. Selected citations for AS 252424 include:

Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol 81 832 PMID: 22434859


Do you know of a great paper that uses AS 252424 from Tocris? If so please let us know.

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