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Biological Activity for AS 252424
AS 252424 is a potent and selective inhibitor of PI 3-kinase γ (IC50 values are 33 and 935 nM for PI 3-Kγ and PI 3-Kα respectively).
Technical Data for AS 252424
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AS 252424
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AS 252424
The following data is based on the product molecular weight 305.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.28 mL||16.38 mL||32.76 mL|
|5 mM||0.66 mL||3.28 mL||6.55 mL|
|10 mM||0.33 mL||1.64 mL||3.28 mL|
|50 mM||0.07 mL||0.33 mL||0.66 mL|
References for AS 252424
References are publications that support the biological activity of the product.
Condliffe et al (2005) Sequential activation of class IB and IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106 1432 PMID: 15878979
Pomel et al (2006) Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. J.Med.Chem. 49 3857 PMID: 16789742
If you know of a relevant reference for AS 252424, please let us know.
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Keywords: AS 252424, AS 252424 supplier, PI3Kgamma, PI3Kγ, PI, 3-kinasegamma, 3-kinaseg, 3-kinaseγ, phosphoinositide, 3, kinases, gamma, γ, signalling, signaling, inositol, lipids, selective, inhibitors, inhibits, AS252424, pi3k, 3-Kinase, 3671, Tocris Bioscience
1 Citation for AS 252424
Citations are publications that use Tocris products. Selected citations for AS 252424 include:
Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol 81 832 PMID: 22434859
Do you know of a great paper that uses AS 252424 from Tocris? Please let us know.
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Literature in this Area
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