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Biological Activity for AS 1892802
AS 1892802 is a potent, ATP-competitive ROCK inhibitor (IC50 values are 52, 57 and 122 nM for human ROCK2, rat ROCK2 and human ROCK1 respectively by ELISA); also inhibits PKAC-α and PRKX (IC50 values are 200 and 325 nM respectively). Exhibits analgesic effects in rat models of inflammatory (AIA) and noninflammatory (MIA) arthritic pain. Orally bioavailable.
Compound Libraries for AS 1892802
Technical Data for AS 1892802
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AS 1892802
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AS 1892802
The following data is based on the product molecular weight 333.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3 mL||15 mL||30 mL|
|5 mM||0.6 mL||3 mL||6 mL|
|10 mM||0.3 mL||1.5 mL||3 mL|
|50 mM||0.06 mL||0.3 mL||0.6 mL|
References for AS 1892802
References are publications that support the biological activity of the product.
Li et al (2012) Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors. J.Med.Chem. 55 2474 PMID: 22272748
Yoshimi et al (2010) Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis. J.Pharmacol.Exp.Ther. 334 955 PMID: 20534789
If you know of a relevant reference for AS 1892802, please let us know.
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Citations for AS 1892802
Citations are publications that use Tocris products.
Currently there are no citations for AS 1892802. Do you know of a great paper that uses AS 1892802 from Tocris? Please let us know.
Reviews for AS 1892802
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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