ARP 100

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Cat.No. 2621 - ARP 100 | C17H20N2O5S | CAS No. 704888-90-4
Description: Selective inhibitor of MMP-2
Chemical Name: 2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Selective inhibitor of MMP-2 (IC50 = 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC50 values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits anti-invasive properties in HT1080 fibrosarcoma cells.

Technical Data

M. Wt 364.42
Formula C17H20N2O5S
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 704888-90-4
PubChem ID 10044321
InChI Key PHGLPDURIUEELR-UHFFFAOYSA-N
Smiles O=S(C1=CC=C(C2=CC=CC=C2)C=C1)(N(OC(C)C)CC(NO)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 364.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Rossello et al (2004) New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorg.Med.Chem. 12 2441 PMID: 15080939

Tuccinardi et al (2006) Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides. Bioorg.Med.Chem. 14 4260 PMID: 16483784


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Keywords: ARP 100, ARP 100 supplier, Selective, inhibitors, inhibits, MMP-2, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, ARP100, 2621, Tocris Bioscience

3 Citations for ARP 100

Citations are publications that use Tocris products. Selected citations for ARP 100 include:

Chetty et al (2010) MMP-2 alters VEGF expression via αVβ3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells. Mol Biol Cell 127 1081 PMID: 20027628

Hensley et al (2012) Combined in vivo molecular and anatomic imaging for detection of ovarian carcinoma-associated protease activity and integrin expression in mice. Neoplasia 14 451 PMID: 22787427

Ji et al (2015) WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-γ pathways. Br J Cancer 113 921 PMID: 26291058


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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