ARN 726

Pricing Availability   Qty
Description: Potent N-acylethanolamine acid amidase (NAAA) inhibitor; NAAA activity-based protein profiling (ABPP) probe
Chemical Name: 4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for ARN 726

ARN 726 is a potent N-acylethanolamine acid amidase (NAAA) inhibitor (IC50 values are 27 nM and 63 nM for human and rat NAAA, respectively). Displays anti-inflammatory effects in human macrophages ex vivo and mouse models of lung inflammation and arthritis. Also used as NAAA activity-based protein profiling (ABPP) probe to detect NAAA in cell lysates or intact cells.

Technical Data for ARN 726

M. Wt 268.35
Formula C14H24N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1628343-77-0
PubChem ID 78319072
InChI Key FNLUJRBWJBUJTC-LBPRGKRZSA-N
Smiles O=C(OCCCCC1CCCCC1)N[C@H]2CNC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ARN 726

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.84 100
ethanol 26.84 100

Preparing Stock Solutions for ARN 726

The following data is based on the product molecular weight 268.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.73 mL 18.63 mL 37.26 mL
5 mM 0.75 mL 3.73 mL 7.45 mL
10 mM 0.37 mL 1.86 mL 3.73 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for ARN 726

References are publications that support the biological activity of the product.

Ribeiro et al (2015) A potent systemically active N-acylethanolamine acid amidase inhibitor that suppresses inflammation and human macrophage activation. ACS Chem.Biol. 10 1838 PMID: 25874594

Romeo et al (2015) Activity-based probe for N-acylethanolamine acid amidase. ACS Chem.Biol. 10 2057 PMID: 26102511

Bonezzi et al (2016) An important role for N-acylethanolamine acid amidase in the complete freund's adjuvant rat model of arthritis. J.Pharmacol.Exp.Ther. 356 656 PMID: 26769918


If you know of a relevant reference for ARN 726, please let us know.

View Related Products by Product Action

View all Other Hydrolase Inhibitors

Keywords: ARN 726, ARN 726 supplier, ARN726, NAAA, N-acylethanolamine, acid, amidase, potent, inhibitors, inhibits, anti, inflammatory, activity, based, protein, profiling, probe, ABPP, Other, Hydrolases, Biochemicals, and, Molecular, Biology, 5861, Tocris Bioscience

Citations for ARN 726

Citations are publications that use Tocris products.

Currently there are no citations for ARN 726. Do you know of a great paper that uses ARN 726 from Tocris? Please let us know.

Reviews for ARN 726

There are currently no reviews for this product. Be the first to review ARN 726 and earn rewards!

Have you used ARN 726?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review