ARN 726

Discontinued Product

ARN 726 (Cat. No. 5861) has been withdrawn from sale for commercial reasons.
Description: Potent N-acylethanolamine acid amidase (NAAA) inhibitor; NAAA activity-based protein profiling (ABPP) probe
Chemical Name: 4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate
Purity: ≥98% (HPLC)

Biological Activity for ARN 726

ARN 726 is a potent N-acylethanolamine acid amidase (NAAA) inhibitor (IC50 values are 27 nM and 63 nM for human and rat NAAA, respectively). Displays anti-inflammatory effects in human macrophages ex vivo and mouse models of lung inflammation and arthritis. Also used as NAAA activity-based protein profiling (ABPP) probe to detect NAAA in cell lysates or intact cells.

Technical Data for ARN 726

M. Wt 268.35
Formula C14H24N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1628343-77-0
PubChem ID 78319072

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ARN 726

References are publications that support the biological activity of the product.

Ribeiro et al (2015) A potent systemically active N-acylethanolamine acid amidase inhibitor that suppresses inflammation and human macrophage activation. ACS Chem.Biol. 10 1838 PMID: 25874594

Romeo et al (2015) Activity-based probe for N-acylethanolamine acid amidase. ACS Chem.Biol. 10 2057 PMID: 26102511

Bonezzi et al (2016) An important role for N-acylethanolamine acid amidase in the complete freund's adjuvant rat model of arthritis. J.Pharmacol.Exp.Ther. 356 656 PMID: 26769918

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Keywords: ARN 726, ARN 726 supplier, ARN726, NAAA, N-acylethanolamine, acid, amidase, potent, inhibitors, inhibits, anti, inflammatory, activity, based, protein, profiling, probe, ABPP, Other, Hydrolases, Biochemicals, and, Molecular, Biology, 5861, Tocris Bioscience

Citations for ARN 726

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Currently there are no citations for ARN 726.

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