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Potent N-acylethanolamine acid amidase (NAAA) inhibitor (IC50 values are 27 nM and 63 nM for human and rat NAAA, respectively). Displays anti-inflammatory effects in human macrophages ex vivo and mouse models of lung inflammation and arthritis. Also used as NAAA activity-based protein profiling (ABPP) probe to detect NAAA in cell lysates or intact cells.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 268.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.73 mL||18.63 mL||37.26 mL|
|5 mM||0.75 mL||3.73 mL||7.45 mL|
|10 mM||0.37 mL||1.86 mL||3.73 mL|
|50 mM||0.07 mL||0.37 mL||0.75 mL|
References are publications that support the biological activity of the product.
Ribeiro et al (2015) A potent systemically active N-acylethanolamine acid amidase inhibitor that suppresses inflammation and human macrophage activation. ACS Chem.Biol. 10 1838 PMID: 25874594
Romeo et al (2015) Activity-based probe for N-acylethanolamine acid amidase. ACS Chem.Biol. 10 2057 PMID: 26102511
Bonezzi et al (2016) An important role for N-acylethanolamine acid amidase in the complete freund's adjuvant rat model of arthritis. J.Pharmacol.Exp.Ther. 356 656 PMID: 26769918
If you know of a relevant reference for ARN 726, please let us know.
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Keywords: ARN 726, ARN 726 supplier, ARN726, NAAA, N-acylethanolamine, acid, amidase, potent, inhibitors, inhibits, anti, inflammatory, activity, based, protein, profiling, probe, ABPP, Other, Hydrolases, Biochemicals, and, Molecular, Biology, 5861, Tocris Bioscience
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