ARN 272

Discontinued Product

ARN 272 (Cat. No. 4574) has been withdrawn from sale for commercial reasons.
Cat.No. 4574 - ARN 272 | C27H20N4O2 | CAS No. 488793-85-7
Description: FAAH-like anandamide transporter (FLAT) inhibitor
Chemical Name: 4-[[4-(4-Hydroxyphenyl)-1-phthalazinyl]amino]-N-phenylbenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

FAAH-like anandamide transporter (FLAT) inhibitor (IC50 = 1.8 μM); cytosolic variant of FAAH-1 that binds anandamide. Attenuates anandamide internalization and deactivation in vitro and in vivo respectively. Exhibits analgesic effects in rodent models of CB1-mediated nociceptive and inflammatory pain.

Technical Data

M. Wt 432.47
Formula C27H20N4O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 488793-85-7
PubChem ID 24802717
InChI Key YNADXFWEXJTQSZ-UHFFFAOYSA-N
Smiles OC(C=C4)=CC=C4C2=NN=C(NC3=CC=C(C(NC5=CC=CC=C5)=O)C=C3)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Piscitelli and Marzo (2012) "Redundancy" of endocannabinoid inactivation: new challenges and opportunities for pain control. ACS Chem.Neurosci. 3 356 PMID: 22860203

Fu et al (2011) A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat.Neurosci. 15 64 PMID: 22101642

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Citations for ARN 272

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Currently there are no citations for ARN 272.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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