ARN 14686

Discontinued Product

ARN 14686 (Cat. No. 5862) has been withdrawn from sale for commercial reasons.
Description: Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe
Chemical Name: (S)-Undec-10-yn-1-yl (2-oxoazetidin-3-yl)carbamate
Purity: ≥98% (HPLC)

Biological Activity for ARN 14686

ARN 14686 is a NAAA (N-acylethanolamine acid amidase) activity-based protein profiling (ABPP) probe. Can be used to detect NAAA in cell lysates or intact cells. Covalently binds the N-terminal cysteine of catalytically active NAAA. Detects catalytically active NAAA in inflamed rat paw in CFA model of inflammation. Potent NAAA inhibitor (IC50 = 6 nM).

Technical Data for ARN 14686

M. Wt 280.36
Formula C15H24N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1628345-10-7
PubChem ID 118915444

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ARN 14686

References are publications that support the biological activity of the product.

Romeo et al (2015) Activity-based probe for N-acylethanolamine acid amidase. ACS Chem.Biol. 10 2057 PMID: 26102511

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Keywords: ARN 14686, ARN 14686 supplier, ARN14686, NAAA, N-acylethanolamine, acid, amidase, activity-based, protein, profiling, ABPP, probes, inhibits, inhibitors, Other, Hydrolases, Biochemicals, and, Molecular, Biology, 5862, Tocris Bioscience

Citations for ARN 14686

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Currently there are no citations for ARN 14686.

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