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ARN 14686 is a NAAA (N-acylethanolamine acid amidase) activity-based protein profiling (ABPP) probe. Can be used to detect NAAA in cell lysates or intact cells. Covalently binds the N-terminal cysteine of catalytically active NAAA. Detects catalytically active NAAA in inflamed rat paw in CFA model of inflammation. Potent NAAA inhibitor (IC50 = 6 nM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 280.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.57 mL||17.83 mL||35.67 mL|
|5 mM||0.71 mL||3.57 mL||7.13 mL|
|10 mM||0.36 mL||1.78 mL||3.57 mL|
|50 mM||0.07 mL||0.36 mL||0.71 mL|
References are publications that support the biological activity of the product.
Romeo et al (2015) Activity-based probe for N-acylethanolamine acid amidase. ACS Chem.Biol. 10 2057 PMID: 26102511
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Keywords: ARN 14686, ARN 14686 supplier, ARN14686, NAAA, N-acylethanolamine, acid, amidase, activity-based, protein, profiling, ABPP, probes, inhibits, inhibitors, Other, Hydrolases, Biochemicals, and, Molecular, Biology, 5862, Tocris Bioscience
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