ARN 14686

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Cat.No. 5862 - ARN 14686 | C15H24N2O3 | CAS No. 1628345-10-7
Description: Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe
Chemical Name: (S)-Undec-10-yn-1-yl (2-oxoazetidin-3-yl)carbamate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

NAAA (N-acylethanolamine acid amidase) activity-based protein profiling (ABPP) probe. Can be used to detect NAAA in cell lysates or intact cells. Covalently binds the N-terminal cysteine of catalytically active NAAA. Detects catalytically active NAAA in inflamed rat paw in CFA model of inflammation. Potent NAAA inhibitor (IC50 = 6 nM).

Technical Data

M. Wt 280.36
Formula C15H24N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1628345-10-7
PubChem ID 118915444
InChI Key XEXRAYPXQNELAS-ZDUSSCGKSA-N
Smiles O=C(OCCCCCCCCCC#C)N[C@H]1CNC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 280.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.57 mL 17.83 mL 35.67 mL
5 mM 0.71 mL 3.57 mL 7.13 mL
10 mM 0.36 mL 1.78 mL 3.57 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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References

References are publications that support the biological activity of the product.

Romeo et al (2015) Activity-based probe for N-acylethanolamine acid amidase. ACS Chem.Biol. 10 2057 PMID: 26102511


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Keywords: ARN 14686, ARN 14686 supplier, ARN14686, NAAA, N-acylethanolamine, acid, amidase, activity-based, protein, profiling, ABPP, probes, inhibits, inhibitors, Other, Hydrolases, Biochemicals, and, Molecular, Biology, 5862, Tocris Bioscience

Citations for ARN 14686

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