ARCC 4 negative control

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Description: Negative control for ARCC 4 (Cat. No. 7254)
Chemical Name: (2S,4S)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for ARCC 4 negative control

ARCC 4 negative control is a negative control for ARCC 4 (Cat. No. 7254). Binds androgen receptors (AR) without inducing degradation.

Technical Data for ARCC 4 negative control

M. Wt 1024.18
Formula C53H56F3N7O7S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2156588-26-8
PubChem ID 145746289
Smiles CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@@H](CN3C([C@H](C(C)(C)C)NC(COCCCCOC4=CC=C(C5=CC=C(N6C(N(C7=CC(C(F)(F)F)=C(C#N)C=C7)C(C6(C)C)=O)=S)C=C5)C=C4)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ARCC 4 negative control

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 102.42 100

Preparing Stock Solutions for ARCC 4 negative control

The following data is based on the product molecular weight 1024.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.98 mL 4.88 mL 9.76 mL
5 mM 0.2 mL 0.98 mL 1.95 mL
10 mM 0.1 mL 0.49 mL 0.98 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

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Product Datasheets for ARCC 4 negative control

References for ARCC 4 negative control

References are publications that support the biological activity of the product.

Salami et al (2018) Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Commun.Biol. 1 100 PMID: 30271980

If you know of a relevant reference for ARCC 4 negative control, please let us know.

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Keywords: ARCC 4 negative control, ARCC 4 negative control supplier, ARCC4, negative, control, PROTAC, PROTACs, degraders, degrades, androgen, receptors, AR, proteolysis-targeting, chimera, prostate, cancer, Negative, Controls, 7255, Tocris Bioscience

Citations for ARCC 4 negative control

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Literature in this Area

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia