Arachidonyl serotonin

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Cat.No. 2836 - Arachidonyl serotonin | C30H42N2O2 | CAS No. 187947-37-1
Description: Dual FAAH inhibitor/TRPV1 antagonist
Alternative Names: AA-5-HT
Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
Datasheet
Citations
Literature

Biological Activity

Dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC50 values are 5.6 μM and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA2, CB1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.

Technical Data

M. Wt 462.67
Formula C30H42N2O2
Storage Store at -20°C
CAS Number 187947-37-1
PubChem ID 10027372
InChI Key QJDNHGXNNRLIGA-DOFZRALJSA-N
Smiles O=C(NCCC1=CNC2=C1C=C(O)C=C2)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 462.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.81 mL 21.61 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Di Marzo et al (2004) The endocannabinoid system and its therapeutic exploitation. Nat.Rev.Drug Discov. 3 771 PMID: 15340387

Maione et al (2007) Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br.J.Pharmacol. 150 766 PMID: 17279090

Bisogno et al (1998) Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem.Biophys.Res.Comms. 248 515 PMID:


If you know of a relevant reference for Arachidonyl serotonin, please let us know.

Keywords: Dual FAAH inhibitors inhibits TRPV1 antagonists cannabinoids Receptors Vanillioid VR1 Channels Transient Receptor Potential Anandamide Amidase Fatty Acid Amide Hydrolases AA5HT AA-5-HT Other Cannabinoids

Citations for Arachidonyl serotonin

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Pathways for Arachidonyl serotonin

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