Arachidonyl serotonin

Discontinued Product

Arachidonyl serotonin (Cat. No. 2836) has been withdrawn from sale for commercial reasons.
Cat.No. 2836 - Arachidonyl serotonin | C30H42N2O2 | CAS No. 187947-37-1
Description: Dual FAAH inhibitor/TRPV1 antagonist
Alternative Names: AA-5-HT
Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for Arachidonyl serotonin

Arachidonyl serotonin is a dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC50 values are 5.6 μM and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA2, CB1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.

Technical Data for Arachidonyl serotonin

M. Wt 462.67
Formula C30H42N2O2
Storage Store at -20°C
CAS Number 187947-37-1
PubChem ID 10027372
InChI Key QJDNHGXNNRLIGA-DOFZRALJSA-N
Smiles O=C(NCCC1=CNC2=C1C=C(O)C=C2)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Arachidonyl serotonin

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References for Arachidonyl serotonin

References are publications that support the biological activity of the product.

Di Marzo et al (2004) The endocannabinoid system and its therapeutic exploitation. Nat.Rev.Drug Discov. 3 771 PMID: 15340387

Maione et al (2007) Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br.J.Pharmacol. 150 766 PMID: 17279090

Bisogno et al (1998) Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem.Biophys.Res.Comms. 248 515

Keywords: Arachidonyl serotonin, Arachidonyl serotonin supplier, Dual, FAAH, inhibitors, inhibits, TRPV1, antagonists, cannabinoids, Receptors, Vanillioid, VR1, Channels, Transient, Receptor, Potential, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, AA5HT, AA-5-HT, Other, Cannabinoids, TRPV, Hydrolase, (FAAH), 2836, Tocris Bioscience

Citations for Arachidonyl serotonin

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Currently there are no citations for Arachidonyl serotonin.

Reviews for Arachidonyl serotonin

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Literature in this Area

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