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Discontinued ProductArachidonyl serotonin (Cat. No. 2836) has been withdrawn from sale for commercial reasons.
Biological Activity for Arachidonyl serotonin
Arachidonyl serotonin is a dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC50 values are 5.6 μM and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA2, CB1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.
Technical Data for Arachidonyl serotonin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Arachidonyl serotonin
References for Arachidonyl serotonin
References are publications that support the biological activity of the product.
Di Marzo et al (2004) The endocannabinoid system and its therapeutic exploitation. Nat.Rev.Drug Discov. 3 771 PMID: 15340387
Maione et al (2007) Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br.J.Pharmacol. 150 766 PMID: 17279090
Bisogno et al (1998) Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem.Biophys.Res.Comms. 248 515
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Keywords: Arachidonyl serotonin, Arachidonyl serotonin supplier, Dual, FAAH, inhibitors, inhibits, TRPV1, antagonists, cannabinoids, Receptors, Vanillioid, VR1, Channels, Transient, Receptor, Potential, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, AA5HT, AA-5-HT, Other, Cannabinoids, TRPV, Hydrolase, (FAAH), 2836, Tocris Bioscience
Citations for Arachidonyl serotonin
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Currently there are no citations for Arachidonyl serotonin.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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