AR-C 66096 tetrasodium salt

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Description: Potent and selective P2Y12 antagonist
Alternative Names: FPL 66096,ARL 66096
Chemical Name: 2-(Propylthio)adenosine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews
Literature (1)

Biological Activity for AR-C 66096 tetrasodium salt

AR-C 66096 tetrasodium salt is a potent and selective P2Y12 receptor antagonist. Blocks ADP-induced inhibition of adenylyl cyclase in vitro (pKB =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC50 = 8.16).

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Technical Data for AR-C 66096 tetrasodium salt

M. Wt 703.26
Formula C14H18F2N5Na4O12P3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 145782-74-7
PubChem ID 90488830
InChI Key IETVOLFQZIGNAQ-HVYRMSERSA-J
Smiles [Na+].[Na+].[Na+].[Na+].CCCSC1=NC(N)=C2N=CN([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)C(F)(F)P([O-])([O-])=O)[C@@H](O)[C@H]3O)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AR-C 66096 tetrasodium salt

Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Product Datasheets for AR-C 66096 tetrasodium salt

Certificate of Analysis / Product Datasheet
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References for AR-C 66096 tetrasodium salt

References are publications that support the biological activity of the product.

Humphries et al (1994) FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors. Br.J.Pharmacol. 113 1057 PMID: 7858849

Ingall et al (1999) Antagonists of the platelet P receptor: a novel approach to antithrombotic therapy. J.Med.Chem. 42 213 PMID: 9925726

Simon et al (2001) Activity of adenosine diphosphates and triphosphates on a P2YT-type receptor in brain capillary endothelial cells. Br.J.Pharmacol. 132 173 PMID: 11156575


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7 Citations for AR-C 66096 tetrasodium salt

Citations are publications that use Tocris products. Selected citations for AR-C 66096 tetrasodium salt include:

Lu et al (2018) The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration. Front Pharmacol 9 242 PMID: 29725296

Chan et al (2018) Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry. Platelets 29 686 PMID: 29715047

Aungraheeta et al (2016) Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood 128 2717 PMID: 27694321

Zhang et al (2014) Agonist-bound structure of the human P2Y12 receptor. Purinergic Signal 509 119 PMID: 24784220


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Reviews for AR-C 66096 tetrasodium salt

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.