AR-C 102222

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Cat.No. 3969 - AR-C 102222 | C19H16F2N6O.HCl | CAS No. 1781934-50-6
Description: Selective iNOS inhibitor
Chemical Name: 5-[(4'-Amino-5',8'-difluorospiro[piperidine-4,2'(1'H)-quinaxolin]-1-yl)carbonyl]-2-pyridinecarbonitrile hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Inducible nitric oxide synthase (iNOS) inhibitor; selective for iNOS over eNOS (IC50 values are 0.037 and >100 μM for iNOS and eNOS respectively). Exhibits antinociceptive and anti-inflammatory activity in rodent pain models.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 418.83
Formula C19H16F2N6O.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1781934-50-6
PubChem ID 21192822
InChI Key FJFMOBYDHGJDGV-UHFFFAOYSA-N
Smiles O=C(C4=CC=C(C#N)N=C4)N(CC3)CCC23N=C(N)C1=C(F)C=CC(F)=C1N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 10.47 25
DMSO 41.86 100

Preparing Stock Solutions

The following data is based on the product molecular weight 418.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.94 mL 23.88 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
10 mM 0.24 mL 1.19 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Keywords: AR-C 102222, AR-C 102222 supplier, AR-C102222, inhibits, inducible, nitric, oxide, synthase, iNOS, inhibitors, selective, astrazeneca, 3969, Tocris Bioscience

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