Inducible nitric oxide synthase (iNOS) inhibitor; selective for iNOS over eNOS (IC50 values are 0.037 and >100 μM for iNOS and eNOS respectively). Exhibits antinociceptive and anti-inflammatory activity in rodent pain models.
Sold with the permission of AstraZeneca UK Ltd.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 418.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.39 mL||11.94 mL||23.88 mL|
|5 mM||0.48 mL||2.39 mL||4.78 mL|
|10 mM||0.24 mL||1.19 mL||2.39 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Tinker et al (2003) 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J.Med.Chem. 46 913 PMID: 12620067
LaBuda et al (2006) Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and postoperative pain. Eur.J.Pain 10 505 PMID: 16125426
Bonnefous et al (2009) Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, Part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models. J.Med.Chem. 52 3047 PMID: 19374401
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Keywords: AR-C102222 inhibits inducible nitric oxide synthase iNOS inhibitors selective astrazeneca iNOS
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