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Submit ReviewAR-C 102222
Description: Selective iNOS inhibitor
Chemical Name: 5-[(4'-Amino-5',8'-difluorospiro[piperidine-4,2'(1'H)-quinaxolin]-1-yl)carbonyl]-2-pyridinecarbonitrile hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for AR-C 102222
AR-C 102222 is an inducible nitric oxide synthase (iNOS) inhibitor; selective for iNOS over eNOS (IC50 values are 0.037 and >100 μM for iNOS and eNOS respectively). Exhibits antinociceptive and anti-inflammatory activity in rodent pain models.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for AR-C 102222
| M. Wt | 418.83 |
| Formula | C19H16F2N6O.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1781934-50-6 |
| PubChem ID | 21192822 |
| InChI Key | FJFMOBYDHGJDGV-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=C(C#N)N=C4)N(CC3)CCC23N=C(N)C1=C(F)C=CC(F)=C1N2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AR-C 102222
References for AR-C 102222
References are publications that support the biological activity of the product.
Tinker et al (2003) 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J.Med.Chem. 46 913 PMID: 12620067
LaBuda et al (2006) Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and postoperative pain. Eur.J.Pain 10 505 PMID: 16125426
Bonnefous et al (2009) Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, Part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models. J.Med.Chem. 52 3047 PMID: 19374401
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Keywords: AR-C 102222, AR-C 102222 supplier, AR-C102222, inhibits, inducible, nitric, oxide, synthase, iNOS, inhibitors, selective, astrazeneca, 3969, Tocris Bioscience
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