APC 366

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Cat.No. 2511 - APC 366 | N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide | CAS No. 158921-85-8
Description: Tryptase inhibitor
Chemical Name: N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective inhibitor of mast cell tryptase (Ki = 7.1 μM) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo.

Technical Data

M. Wt 440.5
Formula C22H28N6O4
Sequence N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
Storage Store at -20°C
CAS Number 158921-85-8
PubChem ID 177340
InChI Key SKYWIMYOGAWOMB-IRXDYDNUSA-N
Smiles OC2=C(C(N[C@@H](CCCNC(N)=N)C(N3[C@H]([C@](N)=O)CCC3)=O)=O)C=CC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 5 mg/ml in 20% ethanol / water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

He et al (1998) A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase. J.Pharmacol.Exp.Ther. 286 289 PMID: 9655871

Barrios et al (1998) Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 63 2295 PMID: 9877219

He et al (2004) Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. J.Pharmacol.Exp.Ther. 309 119 PMID: 14722328

Numerof et al (1997) Tryptase inhibitors: a novel class of anti-inflammatory drugs. Exp.Opin.Invest.Drugs. 6 811


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Keywords: APC 366, APC 366 supplier, Tryptase, inhibitors, inhibits, mast, cell, Proteases, Proteinases, PAR, Receptors, Protease-Activated, proteinase-activated, APC366, Other, 2511, Tocris Bioscience

1 Citation for APC 366

Citations are publications that use Tocris products. Selected citations for APC 366 include:

Matsuda et al (2015) Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury. Am J Transl Res 2015 635041 PMID: 26539519


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Literature in this Area

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