APC 366

Pricing Availability Delivery Time Qty
Cat.No. 2511 - APC 366 | N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide | CAS No. 158921-85-8
Description: Tryptase inhibitor
Chemical Name: N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
Datasheet
Citations (1)
Literature

Biological Activity

Selective inhibitor of mast cell tryptase (Ki = 7.1 μM) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo.

Technical Data

M. Wt 440.5
Formula C22H28N6O4
Sequence N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
Storage Store at -20°C
CAS Number 158921-85-8
PubChem ID 177340
InChI Key SKYWIMYOGAWOMB-IRXDYDNUSA-N
Smiles OC2=C(C(N[C@@H](CCCNC(N)=N)C(N3[C@H]([C@](N)=O)CCC3)=O)=O)C=CC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 5 mg/ml in 20% ethanol / water

Preparing Stock Solutions

The following data is based on the product molecular weight 440.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.14 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

He et al (1998) A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase. J.Pharmacol.Exp.Ther. 286 289 PMID: 9655871

Barrios et al (1998) Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 63 2295 PMID: 9877219

He et al (2004) Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. J.Pharmacol.Exp.Ther. 309 119 PMID: 14722328

Numerof et al (1997) Tryptase inhibitors: a novel class of anti-inflammatory drugs. Exp.Opin.Invest.Drugs. 6 811 PMID:


If you know of a relevant reference for APC 366, please let us know.

View Related Products by Product Action

View all Protease-Activated Receptor Inhibitors

Keywords: APC 366, supplier, Tryptase, inhibitors, inhibits, mast, cell, Proteases, Proteinases, PAR, Receptors, Protease-Activated, proteinase-activated, APC366, Protease-Activated, Receptors, Other, Proteases, Protease-Activated, Receptors, Tocris Bioscience

1 Citation for APC 366

Citations are publications that use Tocris products. Selected citations for APC 366 include:

Matsuda et al (2015) Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury. Am J Transl Res 2015 635041 PMID: 26539519


Do you know of a great paper that uses APC 366 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pathways for APC 366

Protocols

TODO: Add Protocols