Antagonist G

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Cat.No. 1954 - Antagonist G | Arg-D-Trp-N-Methyl-Phe-D-Trp-Leu-Met-NH2 | CAS No. 115150-59-9
Description: Broad spectrum neuropeptide receptor antagonist
Alternative Names: [Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11)
Literature (5)

Biological Activity for Antagonist G

Antagonist G is a substance P analog that is a broad spectrum neuropeptide antagonist and antiproliferative agent. Blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. Inhibits neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro; activates JNK and stimulates apoptosis. Inhibits growth of SCLC xenografts in mice in vivo.

Technical Data for Antagonist G

M. Wt 951.2
Formula C49H66N12O6S
Sequence RWFWLM

(Modifications: Trp-2 = D-Trp, Phe-3 = N-Methyl-Phe, Trp-5 = D-Trp, Met-7 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 115150-59-9
PubChem ID 163960
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Antagonist G

Solubility Soluble to 1 mg/ml in water

References for Antagonist G

References are publications that support the biological activity of the product.

Woll and Rozengurt (1990) A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 50 3968 PMID: 1693879

Langdon et al (1992) Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo. Cancer Res. 52 4554 PMID: 1379515

MacKinnon et al (2000) [Arg6, D-Trp7,9, NmePhe8]-Substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy. Br.J.Cancer 83 941 PMID: 10970698

If you know of a relevant reference for Antagonist G, please let us know.

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Keywords: Antagonist G, Antagonist G supplier, Broad, spectrum, neuropeptide, receptors, antagonists, Tachykinin, Non-Selective, Neurokinin, AntagonistG, neuropeptides, [Arg6,D-Trp7,9,N-MePhe8]-Substance, P(6-11), Other, Peptide, Receptors, 1954, Tocris Bioscience

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