Substance P analog that is a broad spectrum neuropeptide antagonist and antiproliferative agent. Blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. Inhibits neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro; activates JNK and stimulates apoptosis. Inhibits growth of SCLC xenografts in mice in vivo.
(Modifications: Trp-2 = D-Trp, Phe-3 = N-Methyl-Phe, Trp-5 = D-Trp, Met-7 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 951.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.05 mL||5.26 mL||10.51 mL|
|5 mM||0.21 mL||1.05 mL||2.1 mL|
|10 mM||0.11 mL||0.53 mL||1.05 mL|
|50 mM||0.02 mL||0.11 mL||0.21 mL|
References are publications that support the products' biological activity.
Woll and Rozengurt (1990) A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 50 3968 PMID: 1693879
Langdon et al (1992) Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo. Cancer Res. 52 4554 PMID: 1379515
MacKinnon et al (2000) [Arg6, D-Trp7,9, NmePhe8]-Substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy. Br.J.Cancer 83 941 PMID: 10970698
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Keywords: Antagonist G, supplier, Broad, spectrum, neuropeptide, receptors, antagonists, Tachykinin, Non-Selective, Neurokinin, AntagonistG, neuropeptides, [Arg6,D-Trp7,9,N-MePhe8]-Substance, P(6-11), Other, Tachykinin, Other, Peptide, Receptors, Other, Tachykinin, Tocris Bioscience
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.