Discontinued ProductANAVEX 2-73 (Cat. No. 5058) has been withdrawn from sale for commercial reasons.
σ1 agonist (IC50 = 860 nM); also displays affinity for muscarinic M1-M4 receptors (Ki values < 500 nM), but not for σ2 receptors. Exhibits neuroprotective effects, prevents tau hyperphosphorylation, and attenuates scopolamine- and (+)-MK 801-induced learning deficits in a mouse model of amyloid toxicity.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
References are publications that support the biological activity of the product.
Villard et al (2010) Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative. J.Psychopharmacol. 25 1101 PMID: 20829307
Lahmy et al (2013) Blockade of tau hyperphosphorylation and Aβ1-42 generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ1 receptor agonist, in a nontrans Neuropsychopharmacology 38 1706
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Keywords: ANAVEX 2-73, ANAVEX 2-73 supplier, ANAVEX2-73, σ1, sigma1, muscarinic, M1, M2, M3, M4, receptors, agonists, Alzheimers, disease, AD, anti-amnesic, neuroprotective, neuroprotectants, Sigma1, Receptors, Non-selective, Muscarinics, 5058, Tocris Bioscience
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