ANAVEX 2-73

Discontinued Product

Unfortunately ANAVEX 2-73 (Cat. No. 5058) has been withdrawn from sale for commercial reasons.
Cat.No. 5058 - ANAVEX 2-73 | C19H23NO.HCl | CAS No. 195615-84-0
Description: Mixed σ1 and muscarinic receptor agonist; exhibits neuroprotective effects
Chemical Name: Tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

σ1 agonist (IC50 = 860 nM); also displays affinity for muscarinic M1-M4 receptors (Ki values < 500 nM), but not for σ2 receptors. Exhibits neuroprotective effects, prevents tau hyperphosphorylation, and attenuates scopolamine- and (+)-MK 801-induced learning deficits in a mouse model of amyloid toxicity.

Technical Data

M. Wt 317.85
Formula C19H23NO.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 195615-84-0
Smiles CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 317.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.73 mL 31.46 mL
5 mM 0.63 mL 3.15 mL 6.29 mL
10 mM 0.31 mL 1.57 mL 3.15 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Villard et al (2010) Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative. J.Psychopharmacol. 25 1101 PMID: 20829307

Lahmy et al (2013) Blockade of tau hyperphosphorylation and Aβ1-42 generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ1 receptor agonist, in a nontrans Neuropsychopharmacology 38 1706 PMID:

View Related Products by Product Action

View all σ1 Receptor Ligands

Keywords: ANAVEX 2-73, supplier, ANAVEX2-73, σ1, sigma1, muscarinic, M1, M2, M3, M4, receptors, agonists, Alzheimers, disease, AD, anti-amnesic, neuroprotective, neuroprotectants, Sigma1, Receptors, Non-selective, Muscarinics, Sigma1, Receptors, Tocris Bioscience

Citations for ANAVEX 2-73

Citations are publications that use Tocris products.

Currently there are no citations for ANAVEX 2-73.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for ANAVEX 2-73

Protocols

TODO: Add Protocols