Anagrelide hydrochloride

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Cat.No. 2432 - Anagrelide hydrochloride | C10H7Cl2N3O.HCl | CAS No. 58579-51-4
Description: Potent PDE3 inhibitor
Alternative Names: BL 4162A
Chemical Name: 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent type III phosphodiesterase (PDE3) inhibitor (IC50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.

Technical Data

M. Wt 292.55
Formula C10H7Cl2N3O.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 58579-51-4
PubChem ID 42786
InChI Key TVWRQCIPWUCNMI-UHFFFAOYSA-N
Smiles ClC1=C(CN(C3)C(N2)=NC3=O)C2=CC=C1Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.93 10

Preparing Stock Solutions

The following data is based on the product molecular weight 292.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.09 mL 34.18 mL
5 mM 0.68 mL 3.42 mL 6.84 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gillespie (1988) Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity. Biochem.Pharmacol. 37 2866 PMID: 2456068

Mazur et al (1992) Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans. Blood 79 1931 PMID: 1562721

Wang et al (2005) Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures. Br.J.Pharmacol. 146 324 PMID: 16041400


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Keywords: Potent PDE3 inhibitors inhibits Phosphodiesterases BL4162A BL 4162A Phosphodiesterases

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Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
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