Amperozide hydrochloride

Discontinued Product

Amperozide hydrochloride (Cat. No. 2746) has been withdrawn from sale for commercial reasons.
Description: Atypical antipsychotic; high affinity 5-HT2 ligand
Alternative Names: FG 5606
Chemical Name: 4-[4,4-bis(4-Fluorophenyl)butyl]-N-ethyl-1-piperazinecarboxamide hydrochloride
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Amperozide hydrochloride

Atypical antipsychotic that displays high affinity for 5-HT2 receptors (Ki = 26 nM) and low affinity for D2 receptors. Supresses ethanol drinking in genetically ethanol-preferring rats.

Technical Data for Amperozide hydrochloride

M. Wt 437.95
Formula C23H29F2N3O.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 86725-37-3
Smiles FC1=CC=C(C(C3=CC=C(F)C=C3)CCCN2CCN(C(NCC)=O)CC2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Amperozide hydrochloride

References for Amperozide hydrochloride

References are publications that support the biological activity of the product.

Haskins et al (1987) Biochemical and electrophysical studies of the psychotropic compound, amperozide. Brain Res.Bull. 19 465 PMID: 2825928

Meltzer et al (1992) Effect of amperozide on rat cortical 5-HT2 and striatal and limbic DA D2 receptor occupancy: implications for antipsychotic action. Eur.J.Pharmacol. 216 67 PMID: 1388121

Myers et al (1993) 5-HT2 receptor blockade by amperozide suppresses ethanol drinking in genetically preferring rats. Pharmacol.Biochem.Behav. 45 741 PMID: 8332634

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Citations for Amperozide hydrochloride

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Currently there are no citations for Amperozide hydrochloride.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.