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Atypical antipsychotic that displays high affinity for 5-HT2 receptors (Ki = 26 nM) and low affinity for D2 receptors. Supresses ethanol drinking in genetically ethanol-preferring rats.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Haskins et al (1987) Biochemical and electrophysical studies of the psychotropic compound, amperozide. Brain Res.Bull. 19 465 PMID: 2825928
Meltzer et al (1992) Effect of amperozide on rat cortical 5-HT2 and striatal and limbic DA D2 receptor occupancy: implications for antipsychotic action. Eur.J.Pharmacol. 216 67 PMID: 1388121
Myers et al (1993) 5-HT2 receptor blockade by amperozide suppresses ethanol drinking in genetically preferring rats. Pharmacol.Biochem.Behav. 45 741 PMID: 8332634
Keywords: Amperozide hydrochloride, Amperozide hydrochloride supplier, Atypical, antipsychotic, high, affinity, 5-HT2, ligands, Non-Selective, Serotonin, Receptors, FG5606, FG, 5606, Non-selective, 2746, Tocris Bioscience
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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.