Amperozide hydrochloride

Discontinued Product

Unfortunately Amperozide hydrochloride (Cat. No. 2746) has been withdrawn from sale for commercial reasons.
Cat.No. 2746 - Amperozide hydrochloride | C23H29F2N3O.HCl | CAS No. 86725-37-3
Description: Atypical antipsychotic; high affinity 5-HT2 ligand
Alternative Names: FG 5606
Chemical Name: 4-[4,4-bis(4-Fluorophenyl)butyl]-N-ethyl-1-piperazinecarboxamide hydrochloride
Purity: ≥99% (HPLC)

Biological Activity

Atypical antipsychotic that displays high affinity for 5-HT2 receptors (Ki = 26 nM) and low affinity for D2 receptors. Supresses ethanol drinking in genetically ethanol-preferring rats.

Technical Data

M. Wt 437.95
Formula C23H29F2N3O.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 86725-37-3
Smiles FC1=CC=C(C(C3=CC=C(F)C=C3)CCCN2CCN(C(NCC)=O)CC2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 437.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.42 mL 22.83 mL
5 mM 0.46 mL 2.28 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Haskins et al (1987) Biochemical and electrophysical studies of the psychotropic compound, amperozide. Brain Res.Bull. 19 465 PMID: 2825928

Meltzer et al (1992) Effect of amperozide on rat cortical 5-HT2 and striatal and limbic dopamine D2 receptor occupancy: implications for antipsychotic action. Eur.J.Pharmacol. 216 67 PMID: 1388121

Myers et al (1993) 5-HT2 receptor blockade by amperozide suppresses ethanol drinking in genetically preferring rats. Pharmacol.Biochem.Behav. 45 741 PMID: 8332634

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