Discontinued ProductUnfortunately Amperozide hydrochloride (Cat. No. 2746) has been withdrawn from sale for commercial reasons.
Atypical antipsychotic that displays high affinity for 5-HT2 receptors (Ki = 26 nM) and low affinity for D2 receptors. Supresses ethanol drinking in genetically ethanol-preferring rats.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 437.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.28 mL||11.42 mL||22.83 mL|
|5 mM||0.46 mL||2.28 mL||4.57 mL|
|10 mM||0.23 mL||1.14 mL||2.28 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References are publications that support the products' biological activity.
Haskins et al (1987) Biochemical and electrophysical studies of the psychotropic compound, amperozide. Brain Res.Bull. 19 465 PMID: 2825928
Meltzer et al (1992) Effect of amperozide on rat cortical 5-HT2 and striatal and limbic dopamine D2 receptor occupancy: implications for antipsychotic action. Eur.J.Pharmacol. 216 67 PMID: 1388121
Myers et al (1993) 5-HT2 receptor blockade by amperozide suppresses ethanol drinking in genetically preferring rats. Pharmacol.Biochem.Behav. 45 741 PMID: 8332634
Keywords: Amperozide hydrochloride, supplier, Atypical, antipsychotic, high, affinity, 5-HT2, ligands, Non-Selective, Serotonin, Receptors, FG5606, FG, 5606, Non-selective, 5-HT2, Non-selective, 5-HT2, Tocris Bioscience
Citations for Amperozide hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Amperozide hydrochloride.
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Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.