Aminopurvalanol A

Pricing Availability   Qty
Cat.No. 2072 - Aminopurvalanol A | C19H26ClN7O | CAS No. 220792-57-4
Description: Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Alternative Names: NG 97
Chemical Name: (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for Aminopurvalanol A

Aminopurvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 20 - 35 nM for cdk1, cdk2 and cdk5). Also inhibits ERK1 (IC50 = 12.0 μM) and ERK2 (IC50 = 3.1 μM) and is 3000-fold selective over a range of other protein kinases (IC50 >100 μM). Arrests cell cycle at G2/M boundary (IC50 = 1.25 μM), and induces apoptosis at concentrations >10 μM. Cell permeable.

Licensing Information

Sold under license from the Regents of the University of California

Compound Libraries for Aminopurvalanol A

Aminopurvalanol A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Aminopurvalanol A

M. Wt 403.91
Formula C19H26ClN7O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 220792-57-4
PubChem ID 6604931
InChI Key RAMROQQYRRQPDL-HNNXBMFYSA-N
Smiles ClC1=CC(N)=CC(NC2=C3C(N(C(C)C)C=N3)=NC(N[C@H]([C@@H](C)C)CO)=N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Aminopurvalanol A

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.39 100

Preparing Stock Solutions for Aminopurvalanol A

The following data is based on the product molecular weight 403.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.38 mL 24.76 mL
5 mM 0.5 mL 2.48 mL 4.95 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Aminopurvalanol A

References for Aminopurvalanol A

References are publications that support the biological activity of the product.

Chang et al (1999) Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem.Biol. 6 361 PMID: 10375538

Knockaert et al (2000) Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. Chem.Biol. 7 411 PMID: 10873834

Rosiana et al (1999) A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc.Natl.Acad.Sci.USA 96 4797

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987


If you know of a relevant reference for Aminopurvalanol A, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Non-selective CDK Inhibitors

Keywords: Aminopurvalanol A, Aminopurvalanol A supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdk, AminopurvalanolA, NG97, NG, 97, Kinase, Non-selective, CDKs, 2072, Tocris Bioscience

1 Citation for Aminopurvalanol A

Citations are publications that use Tocris products. Selected citations for Aminopurvalanol A include:

Teo et al (2006) An evolutionary conserved role of Wnt signaling in stem cell fate decision. Dev Biol 289 91 PMID: 16309665


Do you know of a great paper that uses Aminopurvalanol A from Tocris? Please let us know.

Reviews for Aminopurvalanol A

There are currently no reviews for this product. Be the first to review Aminopurvalanol A and earn rewards!

Have you used Aminopurvalanol A?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review